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ORIGINAL PAPER
Oedema, infiltration and drainage of connective tissue in rheumatoid arthritis – a preliminary report
Online publication date: 2012-12-21
Reumatologia 2012;50(6):478-486
KEYWORDS
synovial membranelymphatic capillariesspecialized inter-endothelial junctionsimmune cell trafficking
ABSTRACT
Objective: The aim of the study was to visualize lymphatic capillaries (LC) in synovial membrane obtained during synovectomy from patients with rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA).
Material and methods: Specialized inter-endothelial junctions (e.g. endothelial microvalves) were visualized under both a transmission electron microscope (Figs. 1a, b) and light microscope (Figs. 1c, d). These openable junctions enable trafficking of immune cells and drainage of surplus tissue fluid from the interstitium of connective tissue in synovial membrane into prenodal lymph and play a substantial role in the drainage function of LC in synovial joints.
Results: Lymphocytes, macrophages and some debris were found in lumens of LC under the light microscope (Fig. 2). Numerous infiltrates of immune cells in the interstitium of synovial membrane located predominantly around postcapillary venules and in the vicinity of LC
(Fig. 3) were observed.
Conclusion: The role of endothelial microvalves in drainage of inflammatory infiltrates into lymphatic capillaries deserves further investigation.
Material and methods: Specialized inter-endothelial junctions (e.g. endothelial microvalves) were visualized under both a transmission electron microscope (Figs. 1a, b) and light microscope (Figs. 1c, d). These openable junctions enable trafficking of immune cells and drainage of surplus tissue fluid from the interstitium of connective tissue in synovial membrane into prenodal lymph and play a substantial role in the drainage function of LC in synovial joints.
Results: Lymphocytes, macrophages and some debris were found in lumens of LC under the light microscope (Fig. 2). Numerous infiltrates of immune cells in the interstitium of synovial membrane located predominantly around postcapillary venules and in the vicinity of LC
(Fig. 3) were observed.
Conclusion: The role of endothelial microvalves in drainage of inflammatory infiltrates into lymphatic capillaries deserves further investigation.
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Copyright: © Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie. This is an Open Access journal, all articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (https://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
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