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Osteoarthrology
Bialystok osteoporosis study-2: epidemiology of osteoporotic fractures and 10 year fracture risk assessment in population of women in Bialystok region by FRAX™ – WHO algorithm
 
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Online publication date: 2008-04-25
 
 
Reumatologia 2008;46(2):72-79
 
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ABSTRACT
In a randomized cohort of postmenopausal women representative for Bialystok Region BOS-1 we found 14.8% of osteoporosis, 43% of normal results and 42.2% of osteopenia, while 30% of them reported low trauma fractures. 50% of Fx occurred in osteopenic BMD, 24.5% in normal and 25.5% in osteoporotic one. Mean Hip T-score of all Fx was –1.6. In a non-selected cohort of 1608 women in BOS-2, all clinical, independent, risk of fracture (FxRF) were included to evaluate population ten-year probability of major osteoporotic Fx – (hip, clinical spine, forearm or proximal humerus) (m.o.Fx.) as well as hip Fx (h.Fx.) with and without BMD measurement using FRAX™BMI and FRAX™BMD, a WHO Algorithm on the basis of epidemiology in women of the U.K. Results: 10 year probability of m.o.Fx. increased with age from 5.2% with BMD and 4.8% without BMD in the 5th decade to 23.9% and 29.5% respectively in the 9th decade, mean 11.8% with and 11.0% without BMD, and h.Fx from 0.4% and 0.5% to 11.4% and 15.4% mean 3.1% with and 2.8% without BMD respectively. 71% of women with Fx have BMD above hip T-score –2.5 and 18% of those without Fx have BMD below hip T-score –2.5. The results of BOS-1 and BOS-2 studies of epidemiology of osteoporotic fractures indicated that 10-year risk of fracture but not “densitometric osteoporosis” should be diagnostic and therapeutic tool for decision making health care subjects.
Copyright: © Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie. This is an Open Access journal, all articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (https://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
eISSN:2084-9834
ISSN:0034-6233
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