ORIGINAL PAPER
The prevalence of HLA class I and II antigens predisposing to juvenile idiopathic arthritis in the course of idiopathic uveitis among children
Online publication date: 2010-12-20
Reumatologia 2010;48(6):385-390
KEYWORDS
ABSTRACT
Background : Uveitis is one of the most common symptoms of juvenile idiopathic arthritis (JIA). In some cases uveitis may be an isolated feature preceding the typical onset of JIA. The aim was to determine the prevalence of human leukocyte antigens (HLA) which are known as risk factors for the development of JIA and bulb eye involvement in the course of idiopathic uveitis.
Material and methods : 30 patients with idiopathic uveitis and 30 controls were typed for HLA DRB*, DQA*, DQB* alleles, HLA B27 antigen and the presence of antinuclear antibodies.
Results : The mean age at onset of uveitis was 9.6 years. There was no gender difference in the risk of uveitis. HLA B27 was detected in 26.6% of children and ANA in 20% of children. The difference was statistically significant comparing to the controls. Patients carrying B27 antigen and ANA positive presented a recurrent form of uveitis. No associations were found between HLA DRB*, DQA*, DQB alleles and idiopathic uveitis.
Conclusions : The study demonstrates associations between idiopathic uveitis and positivity for HLA B27 antigen and ANA. The results suggest carrying out prospective observation of children with idiopathic uveitis concerning the risk of spondyloarthropathies development.
Material and methods : 30 patients with idiopathic uveitis and 30 controls were typed for HLA DRB*, DQA*, DQB* alleles, HLA B27 antigen and the presence of antinuclear antibodies.
Results : The mean age at onset of uveitis was 9.6 years. There was no gender difference in the risk of uveitis. HLA B27 was detected in 26.6% of children and ANA in 20% of children. The difference was statistically significant comparing to the controls. Patients carrying B27 antigen and ANA positive presented a recurrent form of uveitis. No associations were found between HLA DRB*, DQA*, DQB alleles and idiopathic uveitis.
Conclusions : The study demonstrates associations between idiopathic uveitis and positivity for HLA B27 antigen and ANA. The results suggest carrying out prospective observation of children with idiopathic uveitis concerning the risk of spondyloarthropathies development.
REFERENCES (23)
1.
Alsaeid K, Haider MZ, Sharma PN, et al. The prevalence of human leukocyte antigen (HLA DR/DQ/DP) alleles in Kuwaiti children with oligoarticular juvenile idiopathic arthritis. Rheumatol Int 2006; 26: 224-228. .
2.
Haas JP, Nevinny-Stickel C, Schoenwal U, et al. Susceptible and protective major histocompatibility complex class II alleles in early-onset pauciarticular juvenile chronic arthritis. Human Immunol 1994; 4: 225-233. .
3.
Forre O, Smerdel A. Genetic epidemiology of juvenile idiopathic arthritis. Scanad J Rheumatol 2002; 31: 123-128. .
4.
Murray K, Thompson S, Glass D. Pathogenesis of juvenile chronic arthritis: genetic and enviromental factors. Arch Dis Child 1997; 77: 530-534. .
5.
Vargas-Alarcon G, Londono JD, Hernandez-Pacheco G, et al. Effect of HLA-DR genes on susceptibility to and severity of spondyloarthropathies in Mexican patients. Ann Rheum Dis 2002; 61: 714-717. .
6.
Thomson W, Barret JH, Donn R, et al. Juvenile idiopathic arthritis classified by ILAR criteria: HLA associations in UK patients. Rheumatology 2002; 41: 1183-1189. .
7.
Preiur AM, Chedeville G. Czynniki rokownicze w młodzieńczym idiopatycznym zapaleniu stawów. Curr Opin Rheumatol Rep (wyd. polskie) 2002; 2: 3-10. .
8.
Falcini F, Cimaz R. Młodzieńcze przewlekłe zapalenie stawów. Curr Opin Rheumatol Rep (wyd. polskie) 2001; 1: 1-6. .
9.
Kotaniemi K, Savolainen A, Aho K. Severe uveitis without overt arthritis. Clin Exp Rheumatol 2003; 21: 395-398. .
10.
Wolf MD, Lichter PR, Ragsdale CG. Prognostic factors in the uveitis of juvenile rheumatoid arthritis. Ophtalmology 1987; 94: 1242-1248. .
11.
BenEzra D, Cohen E, Behar-Cohen F. Uveitis and juvenile idiopathic arthritis: A cohort study. Clin Ophtalmol 2007; 14: 513-518. .
12.
Heiligenhaus A, Niewerth M, Ganser G, et al. Prevalence and complications of uveitis in juvenile idiopathic arthritis in a populations-based nation-wide study in Germany: suggested modification of the current screening guidelines. Rheumatology 2007; 46: 1015-1019. .
13.
Saurenmann RK, Levin AV, Feldman BM, et al. Prevalence, risk factors and outcome of uveitis in juvenile idiopathic arthritis. Arthritis Rheum 2007; 56: 647-657. .
14.
Krętowski A, Kinalska I. Geny DQA1 i DQB1 HLA jako markery cukrzycy insulinozależnej w populacji polskiej. Pol Arch Med Wew 1999; 3: 205-210. .
15.
Pratsidou-Gertsi P, Kanakoudi-Tsakalidon F, Spyropoulu, et al. Nationwide collaborative study of class II associations with distinct types of juvenile chronic arthritis (JCA) in Greece. Eur J Immunogenet 1999; 26: 299-310. .
16.
Haas JP, Truckenbrodt H, Paul C, et al. Subtypes of HLA DRB1* 03, *08, *11, *13 and *14 in early onset pauciarticular juvenile chronic arthritis (EOPA) with and without iridocyclitis. Clin Exp Rheumatol 1994; 12 suppl 10: S7-S10. .
17.
Melin-Aldana H, Giannini EH, Taylor J, et al. Human leukocyte antigen DRB1*1104 in the chronic iridocyclitis of pauciarticular juvenile rheumatoid arthritis. J Pediatr 1992; 121: 56-60. .
18.
Fernandez-Melon J, Munoz-Fernandez S, Hidalgo V. Uveitis as the initial clinical manifestation in patients with spondyloarthopaties. J Rheumatol 2004; 31: 524-527. .
19.
Burgos-Vargas R. Juvenile onset spondyloarthropathies: therapeutic aspects. Ann Rheum Dis 2002; 61 (Suppl III): 33-39. .
20.
Kotaniemi K, Savolainen A, Aho K. Severe childhood uveitis without overt arthritis. Clin Exp Rheumatol 2003; 21: 395-398. .
21.
Berk AT, Kocak N, Unsual E. Uveitis in juvenile arthritis. Ocul Immunol Inflamm 2001; 9: 243-251. .
22.
Paroli MP, Speranza S, Marino M, et al. Prognosis of juvenile rheumatoid arthritis-associated uveitis. Eur J Ophthalmol 2003; 13: 616-621. .
23.
Kotaniemi K, Kautainen H, Karma A, Aho K. Occurence of uveitis in recently diagnosed juvenile chronic arthritis. Ophthalmology 2001; 108: 2071-2075.
Copyright: © Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie. This is an Open Access journal, all articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (https://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
Share
RELATED ARTICLE
| eISSN: | 2084-9834 |
| ISSN: | 0034-6233 |
We process personal data collected when visiting the website. The function of obtaining information about users and their behavior is carried out by voluntarily entered information in forms and saving cookies in end devices. Data, including cookies, are used to provide services, improve the user experience and to analyze the traffic in accordance with the Privacy policy. Data are also collected and processed by Google Analytics tool (more).
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
