The role of leptin in inflammatory connective tissue diseases
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Online publication date: 2007-08-30
Reumatologia 2007;45(4):219-224
Leptin is a protein hormone produced mainly by adipocytes. The best known function of leptin has been maintained normal body weight. Leptin also takes part in the cytokine cascade. This protein plays the role of a pro- and antiinflammatory cytokine. Currently leptin is being investigated in many fields of medicine including rheumatology. Up till now leptin has been proposed to be used as a nutritional and prognostic marker in connective tissue diseases. Leptin is also thought to increase incidence of rheumatic diseases. Further studies of anti-leptin therapy should be done because leptin takes part in pathogenesis of connective tissue diseases and modulates immune homeostasis.
Copyright: © Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie. This is an Open Access journal, all articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (https://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
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