GUIDELINES
Diagnosis and treatment of osteoporosis: 2026 recommendations of the Polish Society for Rheumatology
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1
Department of Internal Medicine and Metabolic Disorders, Poznan University of Medical Sciences, Poland
2
Department of Rheumatology, Systemic Connective Tissue Diseases and Immunotherapy of Rheumatic Diseases, Jozef Strus Hospital in Poznan, Poland
3
Department of Paediatrics, Faculty of Medicine and Health Sciences, Andrzej Frycz Modrzewski Krakow University, Poland
4
Early Arthritis Clinic, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland
5
Department of Rheumatology and Immunology, Faculty of Medicine and Health Sciences, Andrzej Frycz Modrzewski Krakow University, Poland
These authors had equal contribution to this work
Submission date: 2026-05-05
Final revision date: 2026-05-28
Acceptance date: 2026-06-10
Online publication date: 2026-06-17
Corresponding author
Cezary Iwaszkiewicz
Department of Rheumatology, Systemic Connective Tissue Diseases and Immunotherapy of Rheumatic Diseases,
Jozef Strus Hospital in Poznan, 3 Szwajcarska St., 61-285 Poznan, Poland
KEYWORDS
TOPICS
ABSTRACT
This publication presents the official recommendations of the Polish Society for Rheumatology for the diagnosis and treatment of osteoporosis. A panel of 6 experienced rheumatologists developed the document using an evidence-informed consensus process incorporating current evidence, clinical experience and the Polish healthcare context. Unanimous agreement was reached on all recommendations. The diagnostic section outlines the diagnostic criteria for osteoporosis in different patient groups and defines, for the first time, the role of radiofrequency echographic multi-spectrometry in clinical practice. The therapeutic section provides guidance on the optimal use of anti-osteoporotic drugs, including sequential therapy, and highlights the benefits of initiating treatment with an anabolic agent in patients at very high fracture risk. The document also addresses prevention of glucocorticoid-induced osteoporosis, osteoporosis in premenopausal women, and diagnosis and treatment in the paediatric population. These recommendations are intended to support early diagnosis and effective management of osteoporosis in Poland.
REFERENCES (158)
1.
Willers C, Norton N, Harvey NC, et al. Osteoporosis in Europe: a compendium of country-specific reports. Arch Osteoporos 2022; 17: 23, DOI: 10.1007/s11657-021-00969-8.
2.
Leszczyński P, Korkosz M, Pawlak-Buś K, et al. Diagnostyka i leczenie osteoporozy – zalecenia Polskiego Towarzystwa Reumatologicznego 2015. Forum Reumatol 2015; 1: 12–24. [Article in Polish].
3.
Peck WA, Burckhardt P, Christiansen C, et al. Consensus development conference: diagnosis, prophylaxis, and treatment of osteoporosis. Am J Med 1993; 94: 646–650, DOI: 10.1016/0002-9343(93)90218-E.
4.
Kanis JA, Cooper C, Rizzoli R, et al. European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporos Int 2019; 30: 3–44, DOI: 10.1007/s00198-018-4704-5.
5.
Krueger D, Tanner SB, Szalat A, et al. DXA reporting updates: 2023 official positions of the International Society for Clinical Densitometry. J Clin Densitom 2024; 27: 101437, DOI: 10.1016/j.jocd.2023.101437.
6.
Iwaszkiewicz C, Leszczyński P. Bone densitometry by radiofrequency echographic multi-spectrometry (REMS) in the diagnosis of osteoporosis. Forum Reumatol 2019; 5: 81–88, DOI: 10.5603/FR.2019.0011.
9.
Diez-Perez A, Brandi ML, Al-Daghri N, et al. Radiofrequency echographic multi-spectrometry for the in-vivo assessment of bone strength: state of the art – outcomes of an expert consensus meeting organized by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO). Aging Clin Exp Res 2019; 31: 1375–1389, DOI: 10.1007/s40520-019-01294-4.
10.
Adami G, Arioli G, Bianchi G, et al. Radiofrequency echographic multi spectrometry for the prediction of incident fragility fractures: a 5-year follow-up study. Bone 2020; 134: 115297, DOI: 10.1016/j.bone.2020.115297.
11.
Cortet B, Dennison E, Diez-Perez A, et al. Radiofrequency echographic multi spectrometry (REMS) for the diagnosis of osteoporosis in a European multicenter clinical context. Bone 2021; 143: 115786, DOI: 10.1016/j.bone.2020.115786.
12.
Icătoiu E, Vlădulescu-Trandafir AI, Groșeanu LM, et al. Radiofrequency echographic multi spectrometry – a novel tool in the diagnosis of osteoporosis and prediction of fragility fractures: a systematic review. Diagnostics (Basel) 2025; 15: 555, DOI: 10.3390/diagnostics15050555.
13.
Fuggle NR, Reginster JY, Al-Daghri N, et al. Radiofrequency echographic multi spectrometry (REMS) in the diagnosis and management of osteoporosis: state of the art. Aging Clin Exp Res 2024; 36: 135, DOI: 10.1007/s40520-024-02784-w.
14.
Caffarelli C, Tomai Pitinca MD, Al Refaie A, et al. Could radiofrequency echographic multispectrometry (REMS) overcome the overestimation in BMD by dual-energy X-ray absorptiometry (DXA) at the lumbar spine? BMC Musculoskelet Disord 2022; 23: 469, DOI: 10.1186/s12891-022-05430-6.
15.
Messina C, Fusco S, Gazzotti S, et al. DXA beyond bone mineral density and the REMS technique: new insights for current radiologists practice. Radiol Med 2024; 129: 1224–1240, DOI: 10.1007/s11547-024-01843-6.
16.
Zambito K, Kushchayeva Y, Bush A, et al. Proposed practice parameters for the performance of radiofrequency echographic multispectrometry (REMS) evaluations. Bone Jt Open 2025; 6: 291–297, DOI: 10.1302/2633-1462.63.BJO-2024-0107.R1.
17.
Harlow SD, Gass M, Hall JE, et al. Executive summary of the Stages of Reproductive Aging Workshop + 10: addressing the unfinished agenda of staging reproductive aging. J Clin Endocrinol Metab 2012; 97: 1159–1168, DOI: 10.1210/jc.2011-3362.
18.
Spiro AJ, Hoang TD, Shakir MKM. Artifacts affecting dual- energy X-ray absorptiometry measurements. AACE Clin Case Rep 2019; 5: e263–e266, DOI: 10.4158/ACCR-2019-0031.
19.
Qutbi M, Soltanshahi M, Shiravand Y, et al. Technical and patient-related sources of error and artifacts in bone mineral densitometry using dual-energy X-ray absorptiometry: a pictorial review. Indian J Radiol Imaging 2020; 30: 362–371, DOI: 10.4103/ijri.IJRI_495_19.
20.
White K, Shakir MKM, Nguyen C, Hoang TD. Artifacts affecting dual-energy X-ray absorptiometry and bone mineral density measurements: a case report and review of the literature. J Med Case Rep 2025; 19: 290, DOI: 10.1186/s13256-025-05353-5.
21.
Yoon BH, Kim DY. Discordance between hip and spine bone mineral density: a point of care. J Bone Metab 2021; 28: 249–251, DOI: 10.11005/jbm.2021.28.4.249.
22.
Singh T, Ghosh A, Khandelwal N, et al. Major and minor discordance in dual-energy X-ray absorptiometry diagnosis of osteoporosis – a cross-sectional, population-based, observational study in Indian women. J Midlife Health 2020; 11: 12–16, DOI: 10.4103/jmh.JMH_117_19.
23.
White VanGompel EC, Franks P, Robbins JA, Fenton JJ. Incidence and predictors of repeat bone mineral densitometry: a longitudinal cohort study. J Gen Intern Med 2017; 32: 1090–1096, DOI: 10.1007/s11606-017-4094-y.
24.
Kobza AO, Herman D, Papaioannou A, et al. Understanding and managing corticosteroid-induced osteoporosis. Open Access Rheumatol 2021; 13: 177–190, DOI: 10.2147/OARRR.S282606.
25.
Miller PD. Guidelines for the diagnosis of osteoporosis: T-scores vs fractures. Rev Endocr Metab Disord 2006; 7: 75–89, DOI: 10.1007/s11154-006-9006-0.
26.
Shuhart CR, Yeap SS, Anderson PA, et al. Executive summary of the 2019 ISCD position development conference on monitoring treatment, DXA cross-calibration and least significant change, spinal cord injury, peri-prosthetic and orthopedic bone health, transgender medicine, and pediatrics. J Clin Densitom 2019; 22: 453–471, DOI: 10.1016/j.jocd.2019.07.001.
27.
Mai HT, Tran TS, Ho-Le TP, et al. Two-thirds of all fractures are not attributable to osteoporosis and advancing age: implications for fracture prevention. J Clin Endocrinol Metab 2019; 104: 3514–3520, DOI: 10.1210/jc.2018-02614.
28.
Siris E, Adler R, Bilezikian J, et al. The clinical diagnosis of osteoporosis: a position statement from the National Bone Health Alliance Working Group. Osteoporos Int 2014; 25: 1439–1443, DOI: 10.1007/s00198-014-2655-z.
29.
Curtis JR, Taylor AJ, Matthews RS, et al. “Pathologic” fractures: should these be included in epidemiologic studies of osteoporotic fractures? Osteoporos Int 2009; 20: 1969–1972, DOI: 10.1007/s00198-009-0840-2.
30.
Kanis JA, Johansson H, Harvey NC, et al. Adjusting conventional FRAX estimates of fracture probability according to the recency of sentinel fractures. Osteoporos Int 2020; 31: 1817–1828, DOI: 10.1007/s00198-020-05517-7.
31.
Ariie T, Yamamoto N, Tsutsumi Y, et al. Association between a history of major osteoporotic fractures and subsequent hip fracture: a systematic review and meta-analysis. Arch Osteoporos 2024; 19: 44, DOI: 10.1007/s11657-024-01393-4.
32.
Warriner AH, Patkar NM, Curtis JR, et al. Which fractures are most attributable to osteoporosis? J Clin Epidemiol 2011; 64: 46–53, DOI: 10.1016/j.jclinepi.2010.07.007.
33.
Weiss RJ, Wick MC, Ackermann PW, Montgomery SM. Increased fracture risk in patients with rheumatic disorders and other inflammatory diseases - a case-control study with 53,108 patients with fracture. J Rheumatol 2010; 37: 2247–2250, DOI: 10.3899/jrheum.100363.
34.
Mok CC, Tse SM, Chan KL, Ho LY. Estimation of fracture risk by the FRAX tool in patients with systemic lupus erythematosus: a 10-year longitudinal validation study. Ther Adv Musculoskelet Dis 2022; 14: 1759720X221074451, DOI: 10.1177/ 1759720X221074451.
35.
Vincze A, Gaál J, Griger Z. Bone health in idiopathic inflammatory myopathies: diagnosis and management. Curr Rheumatol Rep 2021; 23: 55, DOI: 10.1007/s11926-021-01016-8.
36.
Compston J. Glucocorticoid-induced osteoporosis: an update. Endocrine 2018; 61: 7–16, DOI: 10.1007/s12020-018-1588-2.
37.
Kanis JA, Johansson H, McCloskey EV, et al. Rheumatoid arthritis and subsequent fracture risk: an individual person meta- analysis to update FRAX. Osteoporos Int 2025; 36: 653–671, DOI: 10.1007/s00198-025-07397-1.
38.
Lopez C, Parisi S, Parasiliti-Caprino M, et al. Disease activity score is associated with vertebral fragility fractures in patients with rheumatoid arthritis: a cross-sectional multidisciplinary study. Rheumatol Int 2025; 45: 133, DOI: 10.1007/s00296-025-05877-5.
39.
Salman-Monte TC, Sanchez-Piedra C, Fernandez Castro M, et al. Prevalence and factors associated with osteoporosis and fragility fractures in patients with primary Sjögren syndrome. Rheumatol Int 2020; 40: 1259–1265, DOI: 10.1007/s00296-020-04615-3.
40.
Siris ES, Baim S, Nattiv A. Primary care use of FRAX: absolute fracture risk assessment in postmenopausal women and older men. Postgrad Med 2010; 122: 82–90, DOI: 10.3810/pgm.2010.01.2102.
41.
El Miedany Y. FRAX: re-adjust or re-think. Arch Osteoporos 2020; 15: 150, DOI: 10.1007/s11657-020-00827-z.
42.
Schini M, Johansson H, Harvey NC, et al. An overview of the use of the fracture risk assessment tool (FRAX) in osteoporosis. J Endocrinol Invest 2024; 47: 501–511, DOI: 10.1007/s40618-023-02219-9.
43.
Veronese N, Briot K, Guañabens N, et al. Recommendations for the optimal use of bone forming agents in osteoporosis. Aging Clin Exp Res 2024; 36: 167, DOI: 10.1007/s40520-024-02826-3.
44.
Cosman F, Lewiecki EM, Eastell R, et al. Goal-directed osteoporosis treatment: ASBMR/BHOF task force position statement 2024. J Bone Miner Res 2024; 39: 1393–1405, DOI: 10.1093/jbmr/zjae119.
45.
Curtis EM, Reginster JY, Al-Daghri N, et al. Management of patients at very high risk of osteoporotic fractures through sequential treatments. Aging Clin Exp Res 2022; 34: 695–714, DOI: 10.1007/s40520-022-02100-4.
46.
Shevroja E, Reginster JY, Lamy O, et al. Update on the clinical use of trabecular bone score (TBS) in the management of osteoporosis: results of an expert group meeting organized by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO), and the International Osteoporosis Foundation (IOF) under the auspices of WHO Collaborating Center for Epidemiology of Musculoskeletal Health and Aging. Osteoporos Int 2023; 34: 1501–1529, DOI: 10.1007/s00198-023-06817-4.
47.
McCloskey EV, Odén A, Harvey NC, et al. A meta-analysis of trabecular bone score in fracture risk prediction and its relationship to FRAX. J Bone Miner Res 2016; 31: 940–948, DOI: 10.1002/jbmr.2734.
48.
Vasikaran S, Eastell R, Bruyère O, et al. Markers of bone turnover for the prediction of fracture risk and monitoring of osteoporosis treatment: a need for international reference standards. Osteoporos Int 2011; 22: 391–420, DOI: 10.1007/s00198-010-1501-1.
49.
Brescia V, Lovero R, Fontana A, et al. Reference intervals (RIs) of the bone turnover markers (BTMs) in children and adolescents: a proposal for effective use. Biomedicines 2024; 13: 34, DOI: 10.3390/biomedicines13010034.
50.
Bhattoa HP, Cavalier E, Eastell R, et al. Analytical considerations and plans to standardize or harmonize assays for the reference bone turnover markers PINP and -CTX in blood. Clin Chim Acta 2021; 515: 16–20, DOI: 10.1016/j.cca.2020.12.023.
51.
Schini M, Vilaca T, Gossiel F, et al. Bone turnover markers: basic biology to clinical applications. Endocr Rev 2023; 44: 417–473, DOI: 10.1210/endrev/bnac031.
52.
Lewiecki EM. Operationalizing treat-to-target for osteoporosis. Endocrinol Metab (Seoul) 2021; 36: 270–278, DOI: 10.3803/ EnM.2021.970.
53.
Humphrey MB, Russell L, Danila MI, et al. 2022 American College of Rheumatology guideline for the prevention and treatment of glucocorticoid-induced osteoporosis. Arthritis Rheumatol 2023; 75: 2088–2102, DOI: 10.1002/art.42646.
54.
Montero-Odasso M, van der Velde N, Martin FC, et al. World guidelines for falls prevention and management for older adults: a global initiative. Age Ageing 2022; 51: afac205, DOI: 10.1093/ageing/afac205.
55.
O’Reilly T, Gómez Lemus J, Booth L, et al. Potentially inappropriate prescribing and falls-risk increasing drugs in people who have experienced a fall: a systematic review and meta-analysis. Age Ageing 2025; 54: afaf300, DOI: 10.1093/ageing/afaf300.
56.
Pillay J, Gaudet LA, Saba S, et al. Falls prevention interventions for community-dwelling older adults: systematic review and meta- analysis of benefits, harms, and patient values and preferences. Syst Rev 2024; 13: 289, DOI: 10.1186/s13643-024-02681-3.
57.
Dyer SM, Kwok WS, Suen J, et al. Interventions for preventing falls in older people in care facilities. Cochrane Database Syst Rev 2025; 8: CD016064, DOI: 10.1002/14651858.CD016064.
58.
Bae S, Lee S, Park H, et al. Position statement: exercise guidelines for osteoporosis management and fall prevention in osteoporosis patients. J Bone Metab 2023; 30: 149–165, DOI: 10.11005/jbm.2023.30.2.149.
59.
Benedetti MG, Furlini G, Zati A, Letizia Mauro G. The effectiveness of physical exercise on bone density in osteoporotic patients. Biomed Res Int 2018; 2018: 4840531, DOI: 10.1155/2018/4840531.
60.
Lee D, Tak SH, Choi H. A systematic review of fall prevention interventions in frail older adults. Geriatr Nurs 2025; 62: 236–244, DOI: 10.1016/j.gerinurse.2025.02.018.
61.
Sherrington C, Fairhall NJ, Wallbank GK, et al. Exercise for preventing falls in older people living in the community. Cochrane Database Syst Rev 2019; 1: CD012424, DOI: 10.1002/14651858.CD012424.pub2.
62.
Muñoz-Garach A, García-Fontana B, Muñoz-Torres M. Nutrients and dietary patterns related to osteoporosis. Nutrients 2020; 12: 1986, DOI: 10.3390/nu12071986.
63.
Tan B, Su H, Wei L, Liang M. Association of dietary patterns with osteoporosis risk: a meta-analysis of observational studies. J Orthop Surg Res 2025; 20: 551, DOI: 10.1186/s13018-025- 05896-9.
64.
Chen X, Fu Y, Zhu Z. Association between dietary protein intake and bone mineral density based on NHANES 2011-2018. Sci Rep 2025; 15: 8638, DOI: 10.1038/s41598-025-93642-w.
65.
Shea B, Wells G, Cranney A, et al. Calcium supplementation on bone loss in postmenopausal women. Cochrane Database Syst Rev 2004; 1: CD004526, DOI: 10.1002/14651858.CD004526.pub2.
66.
Iwaszkiewicz C, Leszczyński P. The significance of vitamin D in adult orthopaedics and traumatology. Ortop Traumatol Rehabil 2023; 25: 279–285, DOI: 10.5604/01.3001.0053.9676.
67.
Wei FL, Li T, Gao QY, et al. Association between vitamin D supplementation and fall prevention. Front Endocrinol (Lausanne) 2022; 13: 919839, DOI: 10.3389/fendo.2022.919839.
68.
Płudowski P, Ducki C, Konstantynowicz J, Jaworski M. Vitamin D status in Poland. Pol Arch Med Wewn 2016; 126: 530–539, DOI: 10.20452/pamw.3479.
69.
Pludowski P, Takacs I, Boyanov M, et al. Clinical practice in the prevention, diagnosis and treatment of vitamin D deficiency: a Central and Eastern European expert consensus statement. Nutrients 2022; 14: 1483, DOI: 10.3390/nu14071483.
70.
Balachandar R, Pullakhandam R, Kulkarni B, Sachdev HS. Relative efficacy of vitamin D2 and vitamin D3 in improving vitamin D status: systematic review and meta-analysis. Nutrients 2021; 13: 3328, DOI: 10.3390/nu13103328.
71.
Rupprecht M, Wagenpfeil S, Schöpe J, et al. Meta-analysis of European clinical trials characterizing the healthy-adult serum 25-hydroxyvitamin D response to vitamin D supplementation. Nutrients 2023; 15: 3986, DOI: 10.3390/nu15183986.
72.
Rastogi A, Bhansali A, Khare N, et al. Short term, high-dose vitamin D supplementation for COVID-19 disease: a randomised, placebo-controlled study (SHADE study). Postgrad Med J 2022; 98: 87–90, DOI: 10.1136/postgradmedj-2020-139065.
73.
McCullough P, Amend J. Results of daily oral dosing with up to 60,000 international units (iu) of vitamin D3 for 2 to 6 years in 3 adult males. J Steroid Biochem Mol Biol 2017; 173: 308–312, DOI: 10.1016/j.jsbmb.2016.12.009.
74.
Bertoldo F, Cianferotti L, Di Monaco M, et al. Definition, assessment, and management of vitamin D inadequacy: suggestions, recommendations, and warnings from the Italian Society for Osteoporosis, Mineral Metabolism and Bone Diseases (SIOMMMS). Nutrients 2022; 14: 4148, DOI: 10.3390/nu14194148.
75.
Avenell A, Mak JC, O’Connell D. Vitamin D and vitamin D analogues for preventing fractures in post-menopausal women and older men. Cochrane Database Syst Rev 2014; 2014: CD000227, DOI: 10.1002/14651858.CD000227.pub4.
76.
Mott A, Bradley T, Wright K, et al. Effect of vitamin K on bone mineral density and fractures in adults: an updated systematic review and meta-analysis of randomised controlled trials. Osteoporos Int 2019; 30: 1543–1559, DOI: 10.1007/s00198- 019-04949-0.
77.
Foessl I, Dimai HP, Obermayer-Pietsch B. Long-term and sequential treatment for osteoporosis. Nat Rev Endocrinol 2023; 19: 520–533, DOI: 10.1038/s41574-023-00866-9.
78.
Vannala V, Palaian S, Shankar PR. Therapeutic dimensions of bisphosphonates: a clinical update. Int J Prev Med 2020; 11: 166, DOI: 10.4103/ijpvm.IJPVM_33_19.
79.
Wang M, Wu YF, Girgis CM. Bisphosphonate drug holidays: evidence from clinical trials and real-world studies. JBMR Plus 2022; 6: e10629, DOI: 10.1002/jbm4.10629.
80.
Bastounis A, Langley T, Davis S, et al. Assessing the effectiveness of bisphosphonates for the prevention of fragility fractures: an updated systematic review and network meta-analyses. JBMR Plus 2022; 6: e10620, DOI: 10.1002/jbm4.10620.
81.
Zhou J, Ma X, Wang T, Zhai S. Comparative efficacy of bisphosphonates in short-term fracture prevention for primary osteoporosis: a systematic review with network meta-analyses. Osteoporos Int 2016; 27: 3289–3300, DOI: 10.1007/s00198- 016-3654-z.
82.
Wells GA, Hsieh SC, Peterson J, et al. Alendronate for the primary and secondary prevention of osteoporotic fractures in postmenopausal women. Cochrane Database Syst Rev 2025; 1: CD001155, DOI: 10.1002/14651858.CD001155.pub3.
83.
Byun JH, Jang S, Lee S, et al. The efficacy of bisphosphonates for prevention of osteoporotic fracture: an update meta- analysis. J Bone Metab 2017; 24: 37–49, DOI: 10.11005/jbm. 2017.24.1.37.
84.
Chesnut CH, Skag A, Christiansen C, et al. Effects of oral ibandronate administered daily or intermittently on fracture risk in postmenopausal osteoporosis. J Bone Miner Res 2004; 19: 1241–1249, DOI: 10.1359/JBMR.040325.
85.
Laurent MR, Goemaere S, Verroken C, et al. Prevention and treatment of glucocorticoid-induced osteoporosis in adults: consensus recommendations from the Belgian Bone Club. Front Endocrinol (Lausanne) 2022; 13: 908727, DOI: 10.3389/fendo.2022.908727.
86.
Hayat S, Magrey MN. Glucocorticoid-induced osteoporosis: insights for the clinician. Cleve Clin J Med 2020; 87: 417–426, DOI: 10.3949/ccjm.87a.19039.
87.
Allen CS, Yeung JH, Vandermeer B, Homik J. Bisphosphonates for steroid-induced osteoporosis. Cochrane Database Syst Rev 2016; 10: CD001347, DOI: 10.1002/14651858.CD001347.pub2.
88.
Feng Z, Zeng S, Wang Y, et al. Bisphosphonates for the prevention and treatment of osteoporosis in patients with rheumatic diseases: a systematic review and meta-analysis. PLoS One 2013; 8: e80890, DOI: 10.1371/journal.pone.0080890.
89.
Peris P, Monegal A, Guañabens N. Bisphosphonates in inflammatory rheumatic diseases. Bone 2021; 146: 115887, DOI: 10.1016/j.bone.2021.115887.
90.
90 Adams AL. Fracture risk during and after bisphosphonate drug holidays: a matter of methods? Med Care 2020; 58: 417–418, DOI: 10.1097/MLR.0000000000001317.
91.
Bauer DC, Abrahamsen B. Bisphosphonate drug holidays in primary care: when and what to do next? Curr Osteoporos Rep 2021; 19: 182–188, DOI: 10.1007/s11914-021-00660-4.
92.
Dennison EM, Cooper C, Kanis JA, et al. Fracture risk following intermission of osteoporosis therapy. Osteoporos Int 2019; 30: 1733–1743, DOI: 10.1007/s00198-019-05002-w.
93.
Black DM, Geiger EJ, Eastell R, et al. Atypical femur fracture risk versus fragility fracture prevention with bisphosphonates. N Engl J Med 2020; 383: 743–753, DOI: 10.1056/NEJMoa1916525.
94.
Schilcher J, Michaëlsson K, Aspenberg P. Bisphosphonate use and atypical fractures of the femoral shaft. N Engl J Med 2011; 364: 1728–1737, DOI: 10.1056/NEJMoa1010650.
95.
Khan AA, Morrison A, Hanley DA, et al. Diagnosis and management of osteonecrosis of the jaw: a systematic review and international consensus. J Bone Miner Res 2015; 30: 3–23, DOI: 10.1002/jbmr.2405.
96.
Ferrari S, Langdahl B. Mechanisms underlying the long-term and withdrawal effects of denosumab therapy on bone. Nat Rev Rheumatol 2023; 19: 307–317, DOI: 10.1038/s41584-023-00935-3.
97.
Cummings SR, San Martin J, McClung MR, et al. Denosumab for prevention of fractures in postmenopausal women with osteoporosis. N Engl J Med 2009; 361: 756–765, DOI: 10.1056/NEJMoa0809493.
98.
Bone HG, Wagman RB, Brandi ML, et al. 10 years of denosumab treatment in postmenopausal women with osteoporosis: results from the phase 3 randomised FREEDOM trial and open-label extension. Lancet Diabetes Endocrinol 2017; 5: 513–523, DOI: 10.1016/S2213-8587(17)30138-9.
99.
Nayak S, Greenspan SL. A systematic review and meta-analysis of sequential treatment strategies for osteoporosis. Osteoporos Int 2026; 37: 1–13, DOI: 10.1007/s00198-025-07717-5.
100.
Broadwell A, Chines A, Ebeling PR, et al. Denosumab safety and efficacy among participants in the FREEDOM Extension Study with mild to moderate chronic kidney disease. J Clin Endocrinol Metab 2021; 106: 397–409, DOI: 10.1210/clinem/dgaa851.
101.
Gu Z, Yang X, Wang Y, Gao J. Effects of denosumab on bone mineral density and bone metabolism in patients with end-stage renal disease: a systematic review and meta-analysis. Hemodial Int 2023; 27: 352–363, DOI: 10.1111/hdi.13098.
102.
Tang T, Wan B, Zhang A, et al. Efficacy of denosumab in treatment of osteoporosis in patients with rheumatoid arthritis: a meta-analysis of randomized controlled trial. BMC Musculoskelet Disord 2025; 26: 450, DOI: 10.1186/s12891-025-08688-8.
103.
Lau AN, Wong-Pack M, Rodjanapiches R, et al. Occurrence of serious infection in patients with rheumatoid arthritis treated with biologics and denosumab observed in a clinical setting. J Rheumatol 2018; 45: 170–176, DOI: 10.3899/jrheum.161270.
104.
Bruni C, Cigolini C, Tesei G, et al. Combination of denosumab and biologic DMARDs in inflammatory muscle-skeletal diseases and connective tissue diseases. Eur J Rheumatol 2021; 8: 190–195, DOI: 10.5152/eurjrheum.2020.21162.
105.
Mısırcı S, Ekin A, Yağız B, et al. Does the use of denosumab in combination with bDMARDs or tsDMARDs increase the risk of infection in patients with osteoporosis and inflammatory rheumatic diseases? J Clin Med 2025; 14: 6090, DOI: 10.3390/jcm14176090.
106.
Ha J, Lee YJ, Kim J, et al. Long-term efficacy and safety of denosumab: insights beyond 10 years of use. Endocrinol Metab (Seoul) 2025; 40: 47–56, DOI: 10.3803/EnM.2024.2125.
107.
Ferrari S, Lewiecki EM, Butler PW, et al. Favorable skeletal benefit/risk of long-term denosumab therapy: a virtual-twin analysis of fractures prevented relative to skeletal safety events observed. Bone 2020; 134: 115287, DOI: 10.1016/j.bone. 2020.115287.
108.
Tsourdi E, Zillikens MC, Meier C, et al. Fracture risk and management of discontinuation of denosumab therapy: a systematic review and position statement by ECTS. J Clin Endocrinol Metab 2021; 106: 264–281, DOI: 10.1210/clinem/dgaa756.
109.
Lin L, Ren Y, Wang X, Yao Q. Effects of bisphosphonates and denosumab on dental implants: a systematic review with meta-analysis. Oral Dis 2025; 31: 2835–2847, DOI: 10.1111/odi. 15373.
110.
Miller SA, St Onge EL, Whalen KL. Romosozumab: a novel agent in the treatment for postmenopausal osteoporosis. J Pharm Technol 2021; 37: 45–52, DOI: 10.1177/8755122520967632.
111.
Hu M, Zhang Y, Guo J, et al. Meta-analysis of the effects of denosumab and romosozumab on bone mineral density and turnover markers in patients with osteoporosis. Front Endocrinol (Lausanne) 2023; 14: 1188969, DOI: 10.3389/fendo. 2023.1188969.
112.
Saag KG, Petersen J, Brandi ML, et al. Romosozumab or alendronate for fracture prevention in women with osteoporosis. N Engl J Med 2017; 377: 1417–1427, DOI: 10.1056/NEJMoa- 1708322.
113.
Cosman F, Crittenden DB, Adachi JD, et al. Romosozumab treatment in postmenopausal women with osteoporosis. N Engl J Med 2016; 375: 1532–1543, DOI: 10.1056/NEJMoa- 1607948.
114.
Kobayakawa T. Sequential and combination therapy with romosozumab. J Bone Miner Metab 2025; 43: 10–17, DOI: 10.1007/s00774-025-01590-2.
115.
Mochizuki T, Yano K, Ikari K, Okazaki K. Effects of romosozumab or denosumab treatment on the bone mineral density and disease activity for 6 months in patients with rheumatoid arthritis with severe osteoporosis: an open-label, randomized, pilot study. Osteoporos Sarcopenia 2021; 7: 110–114, DOI: 10.1016/j.afos.2021.08.001.
116.
Mochizuki T, Yano K, Ikari K, et al. Comparison of romosozumab versus denosumab treatment on bone mineral density after 1 year in rheumatoid arthritis patients with severe osteoporosis: a randomized clinical pilot study. Mod Rheumatol 2023; 33: 490–495, DOI: 10.1093/mr/roac059.
117.
Kobayakawa T, Miyazaki A, Kanayama Y, et al. Comparable efficacy of denosumab and romosozumab in patients with rheumatoid arthritis receiving glucocorticoid administration. Mod Rheumatol 2023; 33: 96–103, DOI: 10.1093/mr/roac014.
118.
Liu Y, Liu X, Wu Y, Luo T. Efficacy and safety of sequential therapy for primary osteoporosis with bone formation promoters followed by bone resorption inhibitors: a meta-analysis. J Orthop Surg Res 2025; 20: 147, DOI: 10.1186/s13018-025-05545-1.
119.
Roumpou A, Palermo A, Tournis S, et al. Bone in parathyroid diseases revisited: evidence from epidemiological, surgical and new drug outcomes. Endocr Rev 2025; 46: 576–620, DOI: 10.1210/endrev/bnaf010.
120.
Díez-Pérez A, Marin F, Eriksen EF, et al. Effects of teriparatide on hip and upper limb fractures in patients with osteoporosis: a systematic review and meta-analysis. Bone 2019; 120: 1–8, DOI: 10.1016/j.bone.2018.09.020.
121.
Akhter S, Qureshi AR, El-Khechen HA, et al. The efficacy of teriparatide on lumbar spine bone mineral density, vertebral fracture incidence and pain in post-menopausal osteoporotic patients: a systematic review and meta-analysis. Bone Rep 2020; 13: 100728, DOI: 10.1016/j.bonr.2020.100728.
122.
Beaudart C, Veronese N, Douxfils J, et al. PTH1 receptor agonists for fracture risk: a systematic review and network meta- analysis. Osteoporos Int 2025; 36: 951–967, DOI: 10.1007/s00198-025-07440-1.
123.
Ramchand SK, Leder BZ. Sequential therapy for the long-term treatment of postmenopausal osteoporosis. J Clin Endocrinol Metab 2024; 109: 303–311, DOI: 10.1210/clinem/dgad496.
124.
Ebina K, Hirao M, Hashimoto J, et al. Assessment of the effects of switching oral bisphosphonates to denosumab or daily teriparatide in patients with rheumatoid arthritis. J Bone Miner Metab 2018; 36: 478–487, DOI: 10.1007/s00774-017-0861-4.
125.
Kaneko T, Okamura K, Yonemoto Y, et al. Short-term daily teriparatide in patients with rheumatoid arthritis. Mod Rheumatol 2018; 28: 468–473, DOI: 10.1080/14397595.2017.1362093.
126.
Mineta K, Nishisho T, Okada M, et al. Real-world safety and effectiveness of romosozumab following daily or weekly administration of teriparatide in primary and secondary osteoporosis. Bone 2025; 193: 117392, DOI: 10.1016/j.bone.2025. 117392.
127.
Kobayakawa T, Kanayama Y, Hirano Y, et al. Therapy with transitions from one bone-forming agent to another: a retrospective cohort study on teriparatide and romosozumab. JBMR Plus 2024; 8: ziae131, DOI: 10.1093/jbmrpl/ziae131.
128.
Ebina K, Kobayakawa T, Etani Y, et al. Impact of prior teriparatide treatment on the effectiveness of romosozumab in patients with postmenopausal osteoporosis: a case-control study. Bone 2025; 193: 117389, DOI: 10.1016/j.bone.2025.117389.
129.
Ghielmetti A, Grassi G, Zampogna M, et al. Sequential treatment for osteoporosis after teriparatide: a real-life long-term comparison between zoledronic acid and denosumab. J Clin Med 2025; 14: 6360, DOI: 10.3390/jcm14186360.
130.
The 2022 Hormone Therapy Position Statement of The North American Menopause Society Advisory Panel. The 2022 hormone therapy position statement of The North American Menopause Society. Menopause 2022; 29: 767–794, DOI: 10.1097/GME.0000000000002028.
131.
Cauley JA, Robbins J, Chen Z, et al. Effects of estrogen plus progestin on risk of fracture and bone mineral density: the Women’s Health Initiative randomized trial. JAMA 2003; 290: 1729–1738, DOI: 10.1001/jama.290.13.1729.
132.
The Writing Group for the PEPI Trial. Effects of hormone therapy on bone mineral density: results from the postmenopausal estrogen/progestin interventions (PEPI) trial. JAMA 1996; 276: 1389–1396, DOI: 10.1001/jama.1996.03540170033029.
133.
Bofill Rodriguez M, Yong LN, Mirkov S, et al. Long-term hormone therapy for perimenopausal and postmenopausal women. Cochrane Database Syst Rev 2025; 11: CD004143, DOI: 10.1002/14651858.CD004143.pub6.
134.
Anagnostis P, Divaris E, Bosdou JK, et al. Antiosteoporosis therapy after discontinuation of menopausal hormone therapy: a systematic review. Hormones (Athens) 2024; 23: 339–344, DOI: 10.1007/s42000-024-00526-1.
135.
Ascott-Evans BH, Guanabens N, Kivinen S, et al. Alendronate prevents loss of bone density associated with discontinuation of hormone replacement therapy: a randomized controlled trial. Arch Intern Med 2003; 163: 789–794, DOI: 10.1001/archinte.163.7.789.
136.
Vinogradova Y, Iyen B, Masud T, et al. Discontinuation of menopausal hormone therapy and risk of fracture: nested case-control studies using routinely collected primary care data. Lancet Healthy Longev 2025; 6: 100729, DOI: 10.1016/ j.lanhl.2025.100729.
137.
Cho SK, Kim H, Lee J, et al. Effectiveness of bazedoxifene in preventing glucocorticoid-induced bone loss in rheumatoid arthritis patients. Arthritis Res Ther 2021; 23: 176, DOI: 10.1186/s13075-021-02564-1.
138.
Cranney A, Tugwell P, Zytaruk N, et al. Meta-analyses of therapies for postmenopausal osteoporosis. IV. Meta-analysis of raloxifene for the prevention and treatment of postmenopausal osteoporosis. Endocr Rev 2002; 23: 524–528, DOI: 10.1210/er.2001-4002.
139.
Ettinger B, Black DM, Mitlak BH, et al. Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene: results from a 3-year randomized clinical trial. JAMA 1999; 282: 637–645, DOI: 10.1001/jama. 282.7.637.
140.
Siris ES, Harris ST, Eastell R, et al. Skeletal effects of raloxifene after 8 years: results from the continuing outcomes relevant to Evista (CORE) study. J Bone Miner Res 2005; 20: 1514–1524, DOI: 10.1359/JBMR.050509.
141.
Delmas PD, Genant HK, Crans GG, et al. Severity of prevalent vertebral fractures and the risk of subsequent vertebral and nonvertebral fractures: results from the MORE trial. Bone 2003; 33: 522–532, DOI: 10.1016/S8756-3282(03)00241-2.
142.
Visvanathan K, Chlebowski RT, Hurley P, et al. American Society of Clinical Oncology clinical practice guideline update on the use of pharmacologic interventions including tamoxifen, raloxifene, and aromatase inhibition for breast cancer risk reduction. J Clin Oncol 2009; 27: 3235–3258, DOI: 10.1200/JCO.2008.20.5179.
143.
Lippuner K, Buchard PA, De Geyter C, et al. Recommendations for raloxifene use in daily clinical practice in the Swiss setting. Eur Spine J 2012; 21: 2407–2417, DOI: 10.1007/s00586-012-2404-y.
144.
Yang F, Li N, Gaman MA, Wang N. Raloxifene has favorable effects on the lipid profile in women explaining its beneficial effect on cardiovascular risk: a meta-analysis of randomized controlled trials. Pharmacol Res 2021; 166: 105512, DOI: 10.1016/j.phrs.2021.105512.
145.
Ferretti G, Bacchetti T, Simental-Mendía LE, et al. Raloxifene lowers plasma lipoprotein(a) concentrations: a systematic review and meta-analysis of randomized placebo-controlled trials. Cardiovasc Drugs Ther 2017; 31: 197–208, DOI: 10.1007/s10557-017-6721-6.
146.
Martino S, Cauley JA, Barrett-Connor E, et al. Continuing outcomes relevant to Evista: breast cancer incidence in postmenopausal osteoporotic women in a randomized trial of raloxifene. J Natl Cancer Inst 2004; 96: 1751–1761, DOI: 10.1093/jnci/djh319.
147.
Public statement on Protelos: withdrawal of the marketing authorisation in the European Union. Available at:
https://www.ema.europa.eu/en/d...- statement-protelos-withdrawal-marketing-authorisation- european-union_en.pdf (Access: 21.03.2026).
148.
European Medicines Agency recommends limiting long-term use of calcitonin medicines. Available at:
https://www.ema.europa.eu/en/n...- limiting-long-term-use-calcitonin-medicines (Access: 21.03.2026).
149.
Pepe J, Body JJ, Hadji P, et al. Osteoporosis in premenopausal women: a clinical narrative review by the ECTS and the IOF. J Clin Endocrinol Metab 2020; 105: dgaa306, DOI: 10.1210/clinem/dgaa306.
150.
Herath M, Cohen A, Ebeling PR, Milat F. Dilemmas in the management of osteoporosis in younger adults. JBMR Plus 2022; 6: e10594, DOI: 10.1002/jbm4.10594.
151.
Shane E, Shiau S, Recker RR, et al. Denosumab after teriparatide in premenopausal women with idiopathic osteoporosis. J Clin Endocrinol Metab 2022; 107: e1528–e1540, DOI: 10.1210/clinem/dgab850.
152.
Agarwal S, Shane E, Lang T, et al. Spine volumetric BMD and strength in premenopausal idiopathic osteoporosis: effect of teriparatide followed by denosumab. J Clin Endocrinol Metab 2022; 107: e2690–e2701, DOI: 10.1210/clinem/dgac232.
153.
Fujimoto K, Maki N, Hashiba D, et al. Effect of romosozumab in premenopausal women with severe osteoporosis and anorexia nervosa. Osteoporos Sarcopenia 2023; 9: 137–141, DOI: 10.1016/j.afos.2023.10.001.
154.
Ciancia S, van Rijn RR, Högler W, et al. Osteoporosis in children and adolescents: when to suspect and how to diagnose it. Eur J Pediatr 2022; 181: 2549–2561, DOI: 10.1007/s00431-022-04455-2.
155.
Galindo-Zavala R, Bou-Torrent R, Magallares-López B, et al. Expert panel consensus recommendations for diagnosis and treatment of secondary osteoporosis in children. Pediatr Rheumatol Online J 2020; 18: 20, DOI: 10.1186/s12969-020-0411-9.
156.
Ward LM. A practical guide to the diagnosis and management of osteoporosis in childhood and adolescence. Front Endocrinol (Lausanne) 2024; 14: 1266986, DOI: 10.3389/fendo.2023.1266986.
157.
Ciancia S, Högler W, Sakkers RJB, et al. Osteoporosis in children and adolescents: how to treat and monitor? Eur J Pediatr 2023; 182: 501–511, DOI: 10.1007/s00431-022-04743-x.
158.
Zhao H, Ding Y, Yang J, et al. Efficacy and safety of bisphosphonates on childhood osteoporosis secondary to chronic illness or its treatment: a meta-analysis. Ther Adv Chronic Dis 2022; 13: 20406223221129163, DOI: 10.1177/20406223221129163.
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