EN PL
REVIEW PAPER
If something looks like an apple, is it necessarily an apple? Some considerations about so-called “statin-induced polymyalgia rheumatica”
 
 
 
More details
Hide details
1
Internal and Geriatric Medicine Department, Rheumatologic Outpatient Clinic Hospital „Mariano Lauro”, Sant’Agnello, Italy
 
 
Submission date: 2019-06-04
 
 
Acceptance date: 2019-06-18
 
 
Online publication date: 2019-06-28
 
 
Publication date: 2019-06-28
 
 
Reumatologia 2019;57(3):163-166
 
KEYWORDS
TOPICS
ABSTRACT
The existence of polymyalgia rheumatica (PMR) induced by statins has been hypothesised by some investigators. This review article highlights the fact that there is no evidence it is real. On the contrary, PMR and statin-associated muscle symptoms (SAMS) are two totally different conditions. Shoulder and hip ultrasound (US) examinations can make an important contribution in distinguishing a true case of PMR from a PMR-like illness induced by statins. The possibility that SAMS may worsen the clinical manifestations of a PMR patient should be taken into account in clinical practice, and drug discontinuation should be proposed when deterioration or relapse is not otherwise justifiable.
 
REFERENCES (33)
1.
Raheel S, Shbeeb I, Crowson CA, Matteson EL. Epidemiology of polymyalgia rheumatica 2000-2014 and examination of incidence and survival trends over 45 years: a population-based study. Arthritis Care Res 2017; 69: 1282-1285.
 
2.
Cimmino MA, Zaccaria A. Epidemiology of polymyalgia rheumatica. Clin Exp Rheumatol 2000; 18: S9-11.
 
3.
Milchert M, Brzosko M. Diagnosis of polymyalgia rheumatica usually means a favourable outcome for your patient. Indian J Med Res 2017, 145: 593-600.
 
4.
Sobrero A, Manzo C, Stimamiglio A. The role of the general practitioner and the out-of-hospital public rheumatologist in the diagnosis and follow-up of patients with polymyalgia rheumatica. Reumatismo 2018; 70: 44-50.
 
5.
Muratore F, Pazzola G, Pipitone N, Salvarani C. Recent advances in the diagnosis and treatment of polymyalgia rheumatica. Expert Rev Clin Immunol 2016; 12: 1037-1045.
 
6.
Dasgupta B, Cimmino MA, Maradit-Kremers H, et al. 2012 provisional classification criteria for polymyalgia rheumatica: a European League Against Rheumatism/American College of Rheumatology collaborative initiative. Ann Rheum Dis 2012; 71: 484-492.
 
7.
Muratore F, Salvarani C, Macchioni P. Contribution of the new 2012 EULAR/ACR classification criteria for the diagnosis of polymyalgia rheumatica. Reumatismo 2018; 70: 18-22.
 
8.
Manzo C, Milchert M. Polymyalgia rheumatica with normal values of both erythrocyte sedimentation rate and C-reactive protein concentration at the time of diagnosis: a four-point guidance. Reumatologia 2018; 56: 1-2.
 
9.
Manzo C. Polymyalgia rheumatica (PMR) with normal values of both erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) concentration at the time of diagnosis in a centenarian man: A case report. Diseases 2018; 6: pii: E84.
 
10.
Manzo C, Milchert M, Natale M, Brzosko M. Polymyalgia rheumatica with normal values of both erythrocyte sedimentation rate and C-reactive protein concentration at the time of diagnosis. Rheumatology (Oxford) 2019; 5: 921-923.
 
11.
Mackie SL. Polymyalgia rheumatica: pathogenesis and management. Clin Med (London) 2013; 13: 398-400.
 
12.
Tshimologo M, Saunders B, Muller S, et al. Patients’ views on the causes of their polymyalgia rheumatica: a content analysis of data from the PMR Cohort Study. BMJ Open 2017; 7: e014301.
 
13.
Matteson EL, Dejaco C. Polymyalgia rheumatica. Ann Intern Med 2017; 166: ITC65-ITC80.
 
14.
Magni P, Macchi C, Morlotti B, et al. Risk identification and possible countermeasures for muscle adverse effects during statin therapy. Eur J Intern Med 2015; 26: 82-88.
 
15.
Babu S, Li Y. Statin induced necrotizing autoimmune myopathy. J Neurol Sci 2015; 351: 13-17.
 
16.
Maghsoodi N, Wierzbicki AS. Statin myopathy: Over-rated and under-treated? Curr Opin Cardiol 2016; 31: 417-425.
 
17.
Alfirevic A, Neely D, Armitage J, et al. Phenotype standardization for statin-induced myotoxicity. Clin Pharmacol Ther 2014; 96: 470-476.
 
18.
Banach M, Serban C, Sahebkar A, et al. Effects of coenzyme Q10 on statin-induced myopathy: a meta-analysis of randomized controlled trials. Mayo Clin Proc 2015; 90: 24-34.
 
19.
Michalska-Kasiczak M, Sahebkar A, Mikhailidis DP, et al. Analysis of vitamin D levels in patients with and without statin-associated myalgia – A systematic review and metaanalysis of 7 studies with 2420 patients. Int J Cardiol 2014; 178: 111-116.
 
20.
Rudski L, Rabinovitch MA, Danoff D. Systemic immune reactions to HMG-CoA reductase inhibitors. report of 4 cases and review of the literature. Medicine 1998; 77: 378-383.
 
21.
Goëb V, Guillemant N, Vittecoq O, Le Loët X. Cerivastatin-induced polymyalgia rheumatica-like illness. Clin Rheumatol 2004; 23: 179.
 
22.
Kay J, Finn D, Stone J. Case records of the massachusetts general hospital. Case 4–2006. A 79-year-old woman with myalgias, fatigue, and shortness of breath. N Engl J Med 2006; 354: 623-630.
 
23.
De Jong HJI, Saldi SRF, Klungel OH, et al. Statin-Associated Polymyalgia Rheumatica. An Analysis Using WHO Global Individual Case Safety Database: A Case/Non-Case Approach. PLoS One 2012; 7: e41289.
 
24.
Onat SS, Bicer S, Sahin Z, Özbudak Demir S. Is it statin induced polymyalgia rheumatica or just a coincidence? Arch Rheumatol 2015; 30: 261-262.
 
25.
Manzo C, Camellino D. Polymyalgia rheumatica: diagnostic and therapeutic issues of an apparently straightforward disease. Recenti Prog Med 2017; 108: 221-231.
 
26.
Bird HA, Leeb BF, Montecucco CM, et al. A comparison of the sensitivity of diagnostic criteria for polymyalgia rheumatica. Ann Rheum Dis 2005; 64: 626-629.
 
27.
Mackie SL, Koduri G, Hill CL, et al. Accuracy of musculoskeletal imaging for the diagnosis of polymyalgia rheumatica: systematic review. RMD Open 2015; 13: e000100.
 
28.
Falsetti P, Acciai C, Volpe A, et al. Ultrasonography in early assessment of elderly patients with polymyalgic symptoms: a role in predicting diagnostic outcome. Scand J Rheumatol 2011; 40: 57-63.
 
29.
Camellino D, Cimmino MA. Are the new ACR/EULAR criteria the ultimate answer for polymyalgia rheumatica classification? J Rheumatol 2016; 43: 836-838.
 
30.
Helliwell T, Hider SL, Mallen CD. Polymyalgia rheumatica: diagnosis, prescribing and monitoring in general practice. Br J Gen Pract 2013; 63: e361-366.
 
31.
Mathew R, Rashid A. Polymyalgia rheumatica in primary care: managing diagnostic uncertainty. BMJ 2015; 351: h5199.
 
32.
Barraclough K, Liddell WG, du Toit J, et al. Polymyalgia rheumatica in primary care: a cohort study of the diagnostic criteria and out-come. Fam Pract 2008; 25: 328-333.
 
33.
Manzo C, Natale M, Traini E. Diagnosis of polymyalgia rheumatica in primary health care: favoring and confounding factors – a cohort study. Reumatologia 2018; 56: 131-139.
 
Copyright: © Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie. This is an Open Access journal, all articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (https://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
eISSN:2084-9834
ISSN:0034-6233
Journals System - logo
Scroll to top