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3/2014 vol. 52
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PRACA PRZEGLĄDOWA
Nowe aspekty patogenezy spondyloartropatii zapalnych. Część II – czynniki środowiskowe, zaburzenia mikrobiomu, objawy pozastawowe
Ewa Kontny
 
 
 
Więcej
Ukryj
 
Data nadesłania: 03-04-2014
 
 
Data akceptacji: 26-05-2014
 
 
Data publikacji online: 31-07-2014
 
 
Data publikacji: 30-06-2014
 
 
Reumatologia 2014;52(3):172-180
DOI: https://doi.org/10.5114/reum.2014.44087
 
 
Artykuł (PDF)
Referencje (50)
 
SŁOWA KLUCZOWE
zakażenia bakteryjne
mikrobiom
objawy pozastawowe
 
DZIEDZINY
Cytokiny, mediatory zapalenia i odporność w chorobach reumatycznych
Spondyloartropatie - etiologia, patogeneza, obraz kliniczny i leczenie
 
STRESZCZENIE
Spondyloartropatie zapalne (SpA) to grupa chorób o podobnych cechach klinicznych i uwarunkowaniach genetycznych. Zakażenia bakteryjne układu pokarmowego i moczowo-płciowego są głównym czynnikiem środowiskowym związanym z rozwojem SpA. Nowe dane wskazują, że bakterie wewnątrzkomórkowe mogą rozprzestrzeniać zakażenie do innych miejsc anatomicznych. U chorych na SpA często występują objawy pozastawowe, zwłaszcza zapalenie jelit. Postęp w zrozumieniu roli mikrobioty jelitowej w homeostazie oraz nowe dane wskazujące na udział zaburzeń mikrobiomu w rozwoju różnych chorób pozwalają lepiej zrozumieć patogenezę SpA. Przypuszcza się, że SpA może się rozwijać na skutek przeniesienia do stawów odpowiedzi immunologicznej, która jest pierwotnie indukowana w jelicie. Przyczyną zapalenia jelit w SpA może być dysbioza, spowodowana przez czynniki genetyczne i środowiskowe.
REFERENCJE (50)
1.
Kontny E. Nowe aspekty patogenezy spondyloartropatii za­palnych. Część I – uwarunkowania genetyczne, rola cząsteczek HLA-B27. Reumatologia 2014; 52: 105-111. .
Google Scholar
 
 
2.
Chorus AM, Miedema HS, Boonen A, et al. Quality of life and work in patients with rheumatoid arthritis and ankylosing spondylitis of working age. Ann Rhem Dis 2003; 62: 1178-1184. .
Google Scholar
 
 
3.
Robertson LP, Davis MJ. A longitudinal study of disease activity and functional status in a hospital cohort of patients with ankylosing spondylitis. Rheumatology (Oxford) 2004; 43: 1565-1568. .
Google Scholar
 
 
4.
Elewaut D, Matucci-Cerinic M. Treatment of ankylosing spondylitis and extra-articular manifestations in everyday rheumatology practice. Rheumatology (Oxford) 2009; 48: 1029-1035. .
Google Scholar
 
 
5.
Stolwijk C, van Tubergen A, Castillo-Ortiz JD, et al. Prevalence of extra-articular manifestation in patients with ankylosing spondylitis: a systematic review and meta-analysis. Ann Rhem Dis 2013 Sept. doi:10.1136/annrheumdis-2013-203582. .
CrossRef
 
Google Scholar
 
 
6.
Rudwaleit M, van der Heijde D, Landewe R, et al. The development of Assessment of SpondyloArthritis International Society classification criteria for axial spondyloarthritis (part II): validation and final selection. Ann Rheum Dis 2009; 68: 777-83. .
Google Scholar
 
 
7.
Van Praet L, Jans L, Carron P, et al. Degree of bone marrow oedema in sacroiliac joints of patients with axial spondyloarthritis is linked to gut inflammation and male sex: results from the GIANT cohort. Ann Rheum Dis 2014; 73: 1186-1189. .
Google Scholar
 
 
8.
Selmi C, Gershwin ME. Diagnosis and classification of reactive arthritis. Autoimmun Rev 2014; 13: 546-549. .
Google Scholar
 
 
9.
Costello ME, Elewaut D, Kenna TJ, et al. Microbes, the gut and ankylosing spondylitis. Arthritis Res Ther 2013; 15: 214. .
Google Scholar
 
 
10.
Zeidler H, Hudson AP. New insights into Chlamydia and arthritis. Promise of a cure? Ann Rheum Dis 2014; 73: 637-644. .
Google Scholar
 
 
11.
Ge S, He Q, Granfors K. HLA-B27 modulates intracellular growth of Salmonella pathogenicity island 2 mutants and production of cytokines in infected monocytic U937 cells. PloS ONE 2012; 7: e34093. .
Google Scholar
 
 
12.
Cocchiaro JL, Valdivia RH. New insights into Chlamydia intracellular survial mechanisms. Cell Microbiol 2009; 11: 1571-1578. .
Google Scholar
 
 
13.
Berthelot JM, de la Cochetiere MF, Potel G, et al. Evidence supporting a role for dormant bacteria in the pathogenesis of spondyloarthritis. Joint Bone Spine 2013; 80: 135-140. .
Google Scholar
 
 
14.
Gerard HC, Stanich JA, Whittum-Hudson JA, et al. Chlamydia-associated arthritis have ocular (trachoma), not genital, serovars of C. trachomatis in synovial tissue. Microb Pathog 2010; 48: 62-68. .
Google Scholar
 
 
15.
Carter JD, Inman RD. Chlamydia-induced reactive arthritis: hidden in plain sight? Best Pract Res Clin Rheumatol 2011; 25: 359-374. .
Google Scholar
 
 
16.
Carter JD. Bacterial agents in spondyloarthritis; a destiny from diversity? Best Pract Res Clin Rheumatol 2010; 24: 701-714. .
Google Scholar
 
 
17.
Wenink MH, Santegoets KCM, Butcher J, et al. Impaired dendritic cell proinflammatory cytokine production in psoriatic arthritis. Arthritis Rheum 2011; 63: 3313-3322. .
Google Scholar
 
 
18.
Castelino M, Eyre S, Upton M, et al. The bacterial skin microbiome in psoriatic arthritis, an unexplored link in pathogenesis: challenges and opportunities offered by recent technological advances. Rheumatology (Oxford) 2014; 53: 777-784. .
Google Scholar
 
 
19.
Eppinga H, Konstantinov SR, Peppelenbosch MP, et al. The microbiome and psoriatic arthritis. Curr Rheumatol Rep 2014; 16: 407. .
Google Scholar
 
 
20.
Baker PI, Love DR, Ferguson LR. Role of gut microbiota in Crohn’s disease. Expert Rev Gastroenterol Hepatol 2009; 3: 535-546. .
Google Scholar
 
 
21.
Kosiewicz MM, Zirnheld AL, Alard P. Gut microbiota, immunity, and disease: a complex relationship. Front Microbiol 2011; 2: 180. .
Google Scholar
 
 
22.
Strzępa A, Szczepanik M. Wpływ naturalnej flory jelitowej na odpowiedź immunologiczną. Postępy Hig Med Dośw 2013; 67: 908-920. .
Google Scholar
 
 
23.
Korecka A, Arulampalam V. The gut microbiome: scourge, sentinel or spectator? J Oral Microbiol 2012; 4: 9367. .
Google Scholar
 
 
24.
Lopetuso LR, Scaldaferri F, Petito V, et al. Commensal Clostridia: leading players in the maintenance of gut homeostasis. Gut Pathogens 2013; 5: 23. .
Google Scholar
 
 
25.
Khosravi A, Mazmanian SK. Disruption of the gut microbiome as a risk factor for microbial infections. Curr Opin Microbiol 2013; 16: 221-227. .
Google Scholar
 
 
26.
Nutsch KM, Hsieh CS. T cell tolerance and immunity to commensal bacteria. Curr Opin Immunol 2012; 24: 385-391. .
Google Scholar
 
 
27.
Schaeverbeke T, Truchetet ME, Richez Ch. Gut metagenome and spondyloarthritis. Joint Bone Spine 2013; 80: 349-352. .
Google Scholar
 
 
28.
Arumugam M, Raes J, Pelletier E, et al. Enterotypes of the human gut microbiome. Nature 2011; 473: 174-180. .
Google Scholar
 
 
29.
Stebbings S, Munro K, Simon MA, et al. Comparison of the faecal microflora of patients with ankylosing spondylitis and controls using molecular methods of analysis. Rheumatology (Oxford) 2002; 41: 1395-1401. .
Google Scholar
 
 
30.
Gibson G. Growth and activities of sulphate-reducing bacteria in gut contents of healthy subjects and patients with ulcerative colitis. FEMS Microbiol Lett 1991; 86: 103-111. .
Google Scholar
 
 
31.
Stebbings SM, Taylor C, Tannock GW, et al. The immune response to autologous bacteroides in ankylosing spondylitis is characterized by reduced interleukin 10 production. J Rheumatol 2009; 36: 797-800. .
Google Scholar
 
 
32.
Rosenbaum JT, Davey MP. Hypothesis: time for a gut check: HLAB27 predisposes to ankylosing spondylitis by altering the microbiome. Arthritis Rheum 2011; 63: 3195-3198. .
Google Scholar
 
 
33.
Pearson C, Uhlig HH, Powrie F. Lymphoid microenvironments and innate lymphoid cells in the gut. Trends Immunol 2012; 33: 289-295. .
Google Scholar
 
 
34.
Wallace KL, Zheng LB, Kanazawa Y, et al. Immunopathology of inflammatory bowel disease. World J Gastroenterol 2014; 20: 6-21. .
Google Scholar
 
 
35.
Van Praet L, Jacques P, Van den Bosch F, et al. The transition of acute to chronic bowel inflammation in spondyloarthritis. Nat Rev Rheumat 2012; 8: 288-295. .
Google Scholar
 
 
36.
Cherrier M, Ohnmacht C, Cording S, et al. Development and function of intestinal innate lymphoid cells. Curr Opin Immunol 2012; 24: 277-283. .
Google Scholar
 
 
37.
Saltzman NH, Hung K, Haribhai D, et al. Enteric defensins are essential regulators of intestinal microbial ecology. Nat Immunol 2010; 11: 76-82. .
Google Scholar
 
 
38.
Yeoh N, Burton JP, Suppiah P, et al. The role of the microbiome in rheumatic diseases. Curr Rheumatol Rep 2013; 15: 314. .
Google Scholar
 
 
39.
Orlando A, Renna S, Perricone G, et al. Gastrointestinal lesions associated with spondyloarthropathies. World J Gastroenterol 2009; 15: 2443-2448. .
Google Scholar
 
 
40.
Landers CJ, Cohavy O, Misra R, et al. Selected loss of tolerance evidenced by Crohn’s disease-associated immune responses to auto- and microbial antigens. Gastroenterology 2002; 123: 689-699. .
Google Scholar
 
 
41.
Wallis D, Asaduzzaman A, Weisman M, et al. Elevated serum anti-flagellin antibodies implicate subclinical bowel inflammation in ankylosing spondylitis: an observational study. Arthritis Res Ther 2013; 15: R166. .
Google Scholar
 
 
42.
Ciccia F, Alessandro R, Rizzo A, et al. Macrophage phenotype in subclinical gut inflammation of patients with ankylosing spondylitis. Rheumatology (Oxford) 2014; 53: 104-113. .
Google Scholar
 
 
43.
Kenna TJ, Davidson SI, Duan R, et al. Enrichment of circulating interleukin-17-secreting interleukin-23 receptor positive gamma/delta T cells in patients with active ankylosing spondylitis. Arthritis Rheum 2012; 64: 1420-1429. .
Google Scholar
 
 
44.
Roark CL, French JD, Taylor MA, et al. Exacerbation of collagen-induced arthritis by oligoclonal, IL-17-producing gamma delta T cells. J Immunol 2007; 179: 5576-5583. .
Google Scholar
 
 
45.
Nanno M, Kanari Y, Naito T, et al. Exacerbating role of gamma delta T cells in chronic colitis of T-cell receptor alpha mutant mice. Gastroenterology 2008; 134: 481-490. .
Google Scholar
 
 
46.
Ciccia F, Accardo-Palumbo A, Alessandro R, et al. Interleukin-22 and interleukin-22-producing NKp44+ natural killer cells in subclinical gut inflammation in ankylosing spondylitis. Arthritis Rheum 2012; 64: 1869-1878. .
Google Scholar
 
 
47.
Ciccia F, Rizzo A, Accardo-Palumbo A, et al. Increased expression of interleukin-32 in the inflamed ileum of ankylosing spondylitis patients. Rheumatology (Oxford) 2012; 51: 1966-1972. .
Google Scholar
 
 
48.
Fantini MC, Pallone F, Monteleone G. Common immunologic mechanisms in inflammatory bowel disease and spondyloarthropathies. World J Gastroenterol 2009; 15: 2472-2478. .
Google Scholar
 
 
49.
Brakenhoff LK, van der Heijde DM, Hommes DW, et al. The joint-gut axis in inflammatory bowel diseases. J Crohns Colitis 2010; 4: 257-268. .
Google Scholar
 
 
50.
Berer K, Boziki M, Kirshnamoorthy G. Selective accumulation of pro-inflammatory T cells in the intestine contributes to the resistance to autoimmune demyelinating disease. PLoS ONE 2014; 9: e8776.
Google Scholar
 
 
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