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PRACA PRZEGLĄDOWA
Nowe aspekty patogenezy spondyloartropatii zapalnych. Część II – czynniki środowiskowe, zaburzenia mikrobiomu, objawy pozastawowe
 
 
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Data nadesłania: 03-04-2014
 
 
Data akceptacji: 26-05-2014
 
 
Data publikacji online: 31-07-2014
 
 
Data publikacji: 30-06-2014
 
 
Reumatologia 2014;52(3):172-180
 
SŁOWA KLUCZOWE
DZIEDZINY
STRESZCZENIE
Spondyloartropatie zapalne (SpA) to grupa chorób o podobnych cechach klinicznych i uwarunkowaniach genetycznych. Zakażenia bakteryjne układu pokarmowego i moczowo-płciowego są głównym czynnikiem środowiskowym związanym z rozwojem SpA. Nowe dane wskazują, że bakterie wewnątrzkomórkowe mogą rozprzestrzeniać zakażenie do innych miejsc anatomicznych. U chorych na SpA często występują objawy pozastawowe, zwłaszcza zapalenie jelit. Postęp w zrozumieniu roli mikrobioty jelitowej w homeostazie oraz nowe dane wskazujące na udział zaburzeń mikrobiomu w rozwoju różnych chorób pozwalają lepiej zrozumieć patogenezę SpA. Przypuszcza się, że SpA może się rozwijać na skutek przeniesienia do stawów odpowiedzi immunologicznej, która jest pierwotnie indukowana w jelicie. Przyczyną zapalenia jelit w SpA może być dysbioza, spowodowana przez czynniki genetyczne i środowiskowe.
 
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