REVIEW PAPER
Primary Sjögren’s syndrome or manifestations of hepatitis C virus infection?
Online publication date: 2010-12-20
Reumatologia 2010;48(6):442-445
KEYWORDS
ABSTRACT
Chronic hepatitis C virus (HCV) infection in now relatively common. Moreover, frequent associations with HCV infections and connective tissue diseases (CTD), including Sjögren’s syndrome (SS), are observed. It is critical to know if HCV predisposes to or causes CTD or the reported association results from the chance alone. HCV infection and SS manifest with many common symptoms and serological abnormalities. HCV – associated SS is indistinguishable in most cases of the primary syndrome when using 2002 classification criteria. At the same time, HCV infection is one of the exclusions of SS in these criteria. It is controversial. New terms like “SS associated with HCV” or “SS secondary to HCV” are proposed when patients with HCV infection fulfill criteria for SS. The main differences between primary and HCV-related SS are anti-Ro/SS-A and anti-La/SS-B antibodies which are much more frequently detected in the primary form.
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Copyright: © Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie. This is an Open Access journal, all articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (https://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
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