REVIEW PAPER
Primary Sjögren’s syndrome or manifestations of hepatitis C virus infection?
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Online publication date: 2010-12-20
Reumatologia 2010;48(6):442-445
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ABSTRACT
Chronic hepatitis C virus (HCV) infection in now relatively common. Moreover, frequent associations with HCV infections and connective tissue diseases (CTD), including Sjögren’s syndrome (SS), are observed. It is critical to know if HCV predisposes to or causes CTD or the reported association results from the chance alone. HCV infection and SS manifest with many common symptoms and serological abnormalities. HCV – associated SS is indistinguishable in most cases of the primary syndrome when using 2002 classification criteria. At the same time, HCV infection is one of the exclusions of SS in these criteria. It is controversial. New terms like “SS associated with HCV” or “SS secondary to HCV” are proposed when patients with HCV infection fulfill criteria for SS. The main differences between primary and HCV-related SS are anti-Ro/SS-A and anti-La/SS-B antibodies which are much more frequently detected in the primary form.
REFERENCES (19)
1.
Carsons C. Sjögren’s syndrome. Kelley’s Textbook of Rheumatology G.S. Firestein et al. (eds.), 8 edition, Saunders Elsevier 2009; 1149-1168. .
2.
Smyth CM, McKiernan SM, Hagan R, et al. Chronic hepatitis C infection and sicca syndrome: a clear association with HLA DQB1*02. Eur J Gastroenterol-Hepatol 2007; 19: 493-498. .
3.
Madaliński K, Dzierżanowska-Fangrat K, Jóźwiak P i wsp. Rola zakażeń wirusem zapalenia wątroby typu C w patogenezie zespołu Sjögrena. Pol Arch Med Wewn 2002; 107: 167-171. .
4.
Ramos-Casals M, Garcia-Carrasco M, Cervera R, et al. Hepatitis C virus infection mimicking primary Sjögren’s syndrome: a clinical and immunologic description of 35 cases. Medicine 2001; 80: 1-8. .
5.
Ramos-Casals M, Loustaud-Ratti V, De-Vita S, et al. Sjögren’s syndrome associated with hepatitis C virus: a multicenter analysis of 137 cases. Medicine (Baltimore) 2005; 84: 81-89. .
6.
Wener MH, Johnson RJ, Sasso EH, Gretch DR. Hepatitis C virus and rheumatic disease. J Rheumatol 1995; 23: 953-959. .
7.
Durand JM, Lefevre P, Kaplanski G, et al. Sjögren’s syndrome and hepatitis C virus infection. Clin Rheumatol 1995; 14: 570-571. .
8.
Haddad J, Deny P, Munz-Gotheil, et al. Lymphocytic sialadenitis of Sjögren`s syndrome associated with chronic hepatitis C virus liver disease. Lancet 1992; 339: 321-323. .
9.
Arrieta JJ, Rodriguez-Inigo E, Ortiz-Movilla NO, et al. In situ detection of hepatitis C virus RNA in salivary glands. Am J Pathol 2001; 158: 259-264. .
10.
Toussirot E, Le Huédé G, Mougin C, et al. Presence of hepatitis C virus RNA in the salivary glands of patients with Sjögren’s syndrome and hepatitis C virus infection. J Rheumatol 2002; 29: 2382-2385. .
11.
Madaliński K, Godzik P, Zimmermann-Górska I i wsp. Anty-HCV oraz HCV-RNA u chorych z pierwotnym zespołem Sjögrena. Przegląd Epidemiol 2009; 63: 299-304. .
12.
Agnello V, Chung RT, Kaplan LM. A role for hepatitis C virus infection In type II cryoglobulinemia. N Engl J Med 1992; 327: 1490-1495. .
13.
Brito-Zeron P, Ramos-Casals M, Nardi N, et al. Circulating monoclonal immunoglobulins in Sjögren’s syndrome: prevalence and signal significance in 237 patients. Medicine (Baltimore) 2005; 84: 90-97. .
14.
Garcia-Carrasco M, Escarcea RO. Extrahepatic autoimmune manifestations of chronic hepatitis C virus infection. Annal Hepatol 2006; 5: 161-163. .
15.
Gumber SC, Chopra S. Hepatitis C. A multifaceted disease. Review of extrahepatic manifestations. Ann Intern Med 1995; 123: 615-620. .
16.
Madaliński K, Zajączek-Grabowska A, Chwalińska-Sadowska H i wsp. Zjawiska immunologiczne związane z zakażeniem wirusem zapalenia wątroby typu C i ich występowanie w zespole Sjögrena. Reumatologia 1998; 36: 222-225. .
17.
Ramos-Casals M, De-vito S, Tzioufas AG. Hepatitis C virus, Sjögren’s syndrome and B-cell lymphoma: linking infection, autoimmunity and cancer. Autoimmune Rev 2005; 4: 8-15. .
18.
Vitali C, Bombardieri S, Jansson R, et al. Classification criteria for Sjögren’s syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis 2002; 61: 554-558. .
19.
Lovy MR, Starkebaum G, Uberoi S. Hepatitis C infection presenting with rheumatic manifestations: A mimic of rheumatoid arthritis. J Rheumatol 1996; 23: 979-983.
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