REVIEW PAPER
The significance of infections in autoimmune diseases
Online publication date: 2010-04-08
Reumatologia 2009;47(6):332-338
KEYWORDS
ABSTRACT
Development of autoimmune diseases, characterized by the breakdown of self-antigens’ toleration by the immune system, most likely is related to activity of a complex of intrinsic and external factors, including genetic, immunological and hormonal abnormalities, as well as environmental conditions. Among the latter factors, the most important elements seem to be viral, bacterial or parasitic infections. On the other hand, a growing body of evidence indicates that some infectious diseases may also protect against autoimmune disorders. Those potential pathogenic or protective roles of infections in development of autoimmunity are discussed in this article.
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