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6/2009 vol. 47
Pobierz cytowanie
PRACA PRZEGLĄDOWA
Znaczenie infekcji w chorobach autoimmunologicznych
Elżbieta Smolewska
 
 
 
Więcej
Ukryj
 
Data publikacji online: 08-04-2010
 
 
Reumatologia 2009;47(6):332-338
 
Artykuł (PDF)
Referencje (61)
 
SŁOWA KLUCZOWE
infekcja
środowisko
choroby autoimmunologiczne
 
STRESZCZENIE
Do rozwoju chorób autoimmunologicznych, w których dochodzi do przełamania przez układ immunologiczny tolerancji własnych antygenów w rezultacie zadziałania szkodliwych czynników na różne tkanki i narządy, prowadzi prawdopodobnie kompleks czynników endogennych (w tym genetycznych, immunologicznych lub hormonalnych) oraz środowiskowych. Spośród tych ostatnich najważniejszym elementem wydają się różnego typu infekcje, zarówno wirusowe, bakteryjne, jak i pasożytnicze. Wiele obserwacji wskazuje jednak na fakt, że niektóre zakażenia mogą wywierać działanie ochronne przed chorobami z autoagresji. Potencjalnie patogenna lub protekcyjna rola infekcji w rozwoju chorób autoimmunologicznych i prawdopodobne mechanizmy tych zjawisk stanowią przedmiot niniejszej pracy.
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