EN PL
PRACA ORYGINALNA
Poziom cytokin IL-35, TNF-α, BAFF i VEGF w surowicy w różnych chorobach reumatycznych.
 
Więcej
Ukryj
1
Department of Rehabilitation, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland
 
2
Department of Biochemistry and Molecular Biology, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland
 
3
Department of Systemic Connective Tissue Diseases, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland
 
4
Department of Rehabilitation, 1st Faculty of Medicine, Medical University of Warsaw, Poland
 
 
Data nadesłania: 11-06-2019
 
 
Data ostatniej rewizji: 22-06-2019
 
 
Data akceptacji: 22-06-2019
 
 
Data publikacji online: 28-06-2019
 
 
Data publikacji: 28-06-2019
 
 
Reumatologia 2019;57(3):145-150
 
SŁOWA KLUCZOWE
DZIEDZINY
STRESZCZENIE
Objectives:
Inflammatory processes in rheumatic diseases spread via various types of immune system cells and tissues with the aid of inflammatory cytokines and growth factors and the participation of vascular endothelium. Research is still conducted to determine the role of individual factors in the pathophysiology of rheumatic diseases. The task is complicated because the multiplane network of cytokines is characterized by complex correlations manifesting as positive and negative feedback, which impedes the definitive interpretation of the role of specific cytokines. Therefore, it seems justified to perform a comparative analysis of the expression of at least several molecules in one study, which may help reveal their role in the pathogenesis of rheumatic diseases and have prognostic value.

Material and methods:
The aim of the study involves the assessment and comparative analysis of the concentrations of interleukin 35 (IL-35), tumour necrosis factor  (TNF-), B-cell-activating factor (BAFF), and vascular endothelial growth factor (VEGF) in peripheral blood serum in patients with rheumatoid arthritis (RA) (n = 43), systemic lupus erythematosus (SLE) (n = 28), antiphospholipid syndrome (APS) (n = 24), and mixed connective tissue disease (MCTD) (n = 9). The main intention is to search for biomarkers for specific rheumatic diseases. Cytokine and growth factor levels were determined using specific ELISA kits.

Results:
Statistically significant differences in VEGF and IL-35 concentrations occurred between patients with APS vs. RA and SLE vs. RA. There was a significant high positive correlation between the concentration of BAFF and TNF- (r = 0.77, p < 0.0000) in patients with APS, as well as in patients with SLE (r = 0.55, p = 0.00).

Conclusions:
BAFF and TNF- may be promising biomarkers in patients with APS and VEGF in patients with RA. Additionally, IL-35 may be a useful marker for the diagnosis of APS. Positive correlation of BAFF and TNF- concentrations in APS and SLE potentially indicates much more similar etiopathogenesis of these diseases than it could be previously predicted.

 
REFERENCJE (23)
1.
Aringer M, Schulze-Koops H. Immunology of systemic inflammatory diseases. Orthopade 2018; 47: 891-897.
 
2.
Raciborski F, Kłak A, Kwiatkowska B, et al. Diagnostic delays in rheumatic diseases with associated arthritis. Reumatologia 2017; 55: 169-176.
 
3.
Anaya JM, Shoenfeld Y, Buttgereit F, Gonzalez-Gay MA. Autoimmune rheumatic diseases. Biomed Res Int 2014; 2014: 952159.
 
4.
Choi J, Leung PS, Bowlus C, Gershwin ME. IL-35 and Autoimmunity: a Comprehensive Perspective. Clin Rev Allergy Immunol 2015; 49: 327-332.
 
5.
Criscione LG, St Clair EW. Tumor necrosis factor-alpha antagonists for the treatment of rheumatic diseases. Curr Opin Rheumatol 2002; 14: 204-211.
 
6.
Lied GA, Berstad A. Functional and clinical aspects of the B-cell-activating factor (BAFF): a narrative review. Scand J Immunol 2011; 73: 1-7.
 
7.
Holmes DI, Zachary I. The vascular endothelial growth factor (VEGF) family: angiogenic factors in health and disease. Genome Biol 2005; 6: 209.
 
8.
Claesson-Welsh L. VEGF receptor signal transduction – A brief update. Vascul Pharmacol 2016; 86: 14-17.
 
9.
Aletaha D, Neogi T, Silman AJ, et al. 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Ann Rheum Dis 2010; 69: 1580-1588.
 
10.
Tiao J, Feng R, Carr K, et al. Using the American College of Rheumatology (ACR) and Systemic Lupus International Collaborating Clinics (SLICC) criteria to determine the diagnosis of systemic lupus erythematosus (SLE) in patients with subacute cutaneous lupus erythematosus (SCLE). J Am Acad Dermatol 2016; 74: 862-869.
 
11.
Asherson RA, Cervera R, de Groot PG, et al. Catastrophic antiphospholipid syndrome: International consensus statement on classification criteria and treatment guidelines. Lupus 2003; 12: 530-534.
 
12.
Kasukawa R, Too T, Miyawaki S, et al. Preliminary diagnostic criteria for classification of mixed connective tissue disease. In: Mixed connective tissue diseases and anti-nuclear antibodies, Kasukawa R, Sharp GC (eds.). Elsevier, Amsterdam 1987: 41e7.
 
13.
Harada M, Mitsuyama K, Yoshida H, et al. Vascular Endothelial Growth Factor in Patients with Rheumatoid Arthritis. Scand J Rheumatol 1998; 27: 377-380.
 
14.
Ballara S, Taylor PC, Reusch P, et al. Raised serum vascular endothelial growth factor levels are associated with destructive change in inflammatory arthritis. Arthritis Rheum 2001; 44: 2055-2064.
 
15.
Lee SS, Joo YS, Kim WU, et al. Vascular endothelial growth factor levels in the serum and synovial fluid of patients with rheumatoid arthritis. Clin Exp Rheumatol 2001; 19: 321-324.
 
16.
Smets P, Devauchelle-Pensec V, Rouzaire PO, et al. Vascular endothelial growth factor levels and rheumatic diseases of the elderly. Arthritis Res Ther 2016; 18: 283.
 
17.
Arima K, Origuchi T, Tamai M, et al. RS3PE syndrome presenting as vascular endothelial growth factor associated disorder. Ann Rheum Dis 2005; 64: 1653-1655.
 
18.
Yoo SA, Kwok SK, Kim WU. Proinflammatory role of vascular endothelial growth factor in the pathogenesis of rheumatoid arthritis: prospects for therapeutic intervention. Mediators Inflamm 2008; 2008: 129873.
 
19.
Roy H, Bhardwaj S, Ylä-Herttuala S. Biology of vascular endothelial growth factors. FEBS Lett 2006; 580: 2879-2887.
 
20.
Ning X, Jian Z, Wang W. Low Serum Levels of Interleukin 35 in Patients with Rheumatoid Arthritis. Tohoku J Exp Med 2015; 237: 77-82.
 
21.
Jiang S, Li Y, Lin T, et al. IL-35 Inhibits Angiogenesis through VEGF/Ang2/Tie2 Pathway in Rheumatoid Arthritis. Cell Physiol Biochem 2016; 40: 1105-1116.
 
22.
Álvarez-Rodríguez L, Martínez-Taboada V, Calvo-Alén J, et al. Altered Th17/Treg Ratio in Peripheral Blood of Systemic Lupus Erythematosus but Not Primary Antiphospholipid Syndrome. Front Immunol 2019; 10: 391.
 
23.
Sang M, Li J, Wei Z, et al. Molecular structure, expression, and bioactivity of B-cell-activating factor of the TNF family (BAFF) and its receptor BAFF-R in cats (Felis catus). Mol Immunol 2019; 112: 59-71.
 
Copyright: © Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie. This is an Open Access journal, all articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (https://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
eISSN:2084-9834
ISSN:0034-6233
Journals System - logo
Scroll to top