Interactions between microbiota, diet/nutrients and immune/inflammatory response in rheumatic diseases: focus on rheumatoid arthritis
Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS San Martino Polyclinic Hospital, Genova, Italy
Data nadesłania: 26-04-2019
Data ostatniej rewizji: 28-05-2019
Data akceptacji: 28-05-2019
Data publikacji online: 28-06-2019
Data publikacji: 28-06-2019
Reumatologia 2019;57(3):151-157
Rheumatic and musculoskeletal diseases (RMDs) are chronic systemic immune/inflammatory conditions characterized by the interaction between gene predisposition, autoimmunity and environmental factors. A growing scientific interest has focused on the role of diet in RMDs, suggesting its significant contribution to the pathogenesis and prognosis of these diseases. It is now clear that diet can directly modulate the immune response by providing a wide range of nutrients, which interfere with multiple pathways at both the gastro-intestinal and systemic level. Moreover, diet critically shapes the human gut microbiota, which is recognized to have a central role in the modulation of the immune response and in RMD pathogenesis. We hereby provide an in-depth analysis on the role of the microbiota in RMDs and on nutritional intervention as an integral part of a multidisciplinary approach. Particular attention will be given to the Mediterranean diet, as the only diet proven to support substantial benefits in RMD management.
Dahan S, Segal Y, Shoenfeld Y. Dietary factors in rheumatic autoimmune diseases: A recipe for therapy? Nat Rev Rheumatol 2017; 13: 348-358.
Cutolo M, Nikiphorou E. Don’t neglect nutrition in rheumatoid arthritis! RMD Open 2018; 4: e000591.
Han M, Wang C, Liu P, et al. Dietary Fiber Gap and Host Gut Microbiota. Protein Pept Lett 2017; 24: 388-396.
Abdollahi-Roodsaz S, Abramson SB, Scher JU. The metabolic role of the gut microbiota in health and rheumatic disease: mechanisms and interventions. Nat Rev Rheumatol 2016; 12: 446-455.
Schroeder BO, Bäckhed F. Signals from the gut microbiota to distant organs in physiology and disease. Nat Med 2016; 22: 1079-1089.
Zuo T, Kamm MA, Colombel JF, et al. Urbanization and the gut microbiota in health and inflammatory bowel disease. Nat Rev Gastroenterol Hepatol 2018; 15: 440-452.
Trompette A, Gollwitzer ES, Yadava K, et al. Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis. Nat Med 2014; 20: 159-166.
Van de Wiele T, Van Praet JT, Marzorati M, et al. How the Microbiota Shapes Rheumatic Diseases. Nat Rev Rheumatol 2016; 12: 398-411.
Zechner EL. Inflammatory disease caused by intestinal pathobionts. Curr Opin Microbiol 2017; 35: 64-69.
Lynch SV, Pedersen O. The Human Intestinal Microbiome in Health and Disease. N Engl J Med 2016; 375: 2369-2379.
Alpizar-Rodriguez D, Lesker TR, Gronow A, et al. Prevotella copri in individuals at risk for rheumatoid arthritis. Ann Rheum Dis 2019; 78: 590-593.
Jethwa H, Abraham S. The evidence for microbiome manipulation in inflammatory arthritis. Rheumatology (Oxford) 2017; 56: 1452-1462.
Chimenti MS, Perricone C, Novelli L, et al. Interaction between microbiome and host genetics in psoriatic arthritis. Autoimmun Rev 2018; 17: 276-283.
Rodríguez-Carrio J, López P, Sánchez B, et al. Intestinal Dysbiosis Is Associated with Altered Short-Chain Fatty Acids and Serum-Free Fatty Acids in Systemic Lupus Erythematosus. Front Immunol 2017; 8: 23.
Luo XM, Edwards MR, Mu Q, et al. Gut Microbiota in Human Systemic Lupus Erythematosus and a Mouse Model of Lupus. Appl Environ Microbiol 2017; 84: e02288-17.
Liu Y, Alookaran JJ, Rhoads JM. Probiotics in Autoimmune and Inflammatory Disorders. Nutrients 2018; 10: e1537.
Kim JE, Chang SC, Kim GC, et al. Lactobacillus helveticus suppresses experimental rheumatoid arthritis by reducing inflammatory T cell responses. J Funct Foods 2015; 13: 350-362.
Derrien M, Veiga P. Rethinking Diet to Aid Human–Microbe Symbiosis. Trends Microbiol 2017; 25: 100-112.
Deehan EC, Walter J. The Fiber Gap and the Disappearing Gut Microbiome: Implications for Human Nutrition. Trends Endocrinol Metab 2016; 27: 239-242.
Zinöcker M, Lindseth I. The Western Diet – Microbiome-Host Interaction and Its Role in Metabolic Disease. Nutrients 2018; 10: e365.
De Filippo C, Cavalieri D, Di Paola M, et al. Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proc Natl Acad Sci USA 2010; 107: 14691-14696.
Wilck MG, Matus SM, Kearney SM, et al. Salt-responsive gut commensal modulates TH17 axis and disease. Nature 2017; 551: 585-589.
Sharif K, Amital H, Shoenfeld Y. The role of dietary sodium in autoimmune diseases: The salty truth. Autoimmun Rev 2018; 17: 1069-1073.
Hu Y, Sparks JA, Malspeis S, et al. Long-term dietary quality and risk of developing rheumatoid arthritis in women. Ann Rheum Dis 2017; 76: 1357-1364.
McKellar G, Morrison E, McEntegart A. A pilot study of a Mediterranean-type diet intervention in female patients with rheumatoid arthritis living in areas of social deprivation in Glasgow. Ann Rheum Dis 2007; 66: 1239-1243.
Khanna S, Jaiswal KS, Gupta B. Managing Rheumatoid Arthritis with Dietary Interventions. Front Nutr 2017; 4: 52.
Oliveira A, Monteiro V, Navegantes-Lima K, et al. Resveratrol Role in Autoimmune Disease – A Mini-Review. Nutrients 2017; 9: e1306.
Kunnumakkara AB, Bordoloi D, Padmavathi G, et al. Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases. Br J Pharmacol 2017; 174: 1325-1348.
Kim H-S, Quon MJ, Kim J. New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate. Redox Biol 2014; 2: 187-195.
Gioxari A, Kaliora AC, Marantidou F, et al. Intake of -3 polyunsaturated fatty acids in patients with rheumatoid arthritis: A systematic review and meta-analysis. Nutrition 2018; 45: 114-124.e4.
Di Giuseppe D, Crippa A, Orsini N, et al. Fish consumption and risk of rheumatoid arthritis: a dose-response meta-analysis. Arthritis Res Ther 2014; 16: 446.
Rosillo MA, Sánchez-Hidalgo M, Sánchez-Fidalgo S, et al. Dietary extra-virgin olive oil prevents inflammatory response and cartilage matrix degradation in murine collagen-induced arthritis. Eur J Nutr 2016; 55: 315-325. Matsumoto Y, Sugioka Y, Tada M, et al. Monounsaturated fatty acids might be key factors in the.
Mediterranean diet that suppress rheumatoid arthritis disease activity: The TOMORROW study. Clin Nutr 2018; 37: 675-680.
Pang K-L, Chin K-Y. The Biological Activities of Oleocanthal from a Molecular Perspective. Nutrients 2018; 10: e570.
Granic A, Sayer AA, Robinson SM. Dietary Patterns, Skeletal Muscle Health, and Sarcopenia in Older Adults. Nutrients 2019; 11: e745.
Malmir H, Saneei P, Larijani B, et al. Adherence to Mediterranean diet in relation to bone mineral density and risk of fracture: a systematic review and meta-analysis of observational studies. Eur J Nutr 2018; 57: 2147-2160.
Cutolo M, Straub RH. Circadian rhythms in arthritis: Hormonal effects on the immune/inflammatory reaction. Autoimmunity Rev 2008; 7: 223-228.
Sulli A, Maestroni GJ, Villaggio B, et al. Melatonin serum levels in rheumatoid arthritis. Ann NY Acad Sci 2002; 966: 276-283.
Masi AT, Bijlsma JW, Chikanza IC, et al. Neuroendocrine, immunologic, and microvascular systems interactions in rheumatoid arthritis: physiopathogenetic and therapeutic perspectives. Semin Arthritis Rheum 1999; 29: 65-68.
Copyright: © Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie. This is an Open Access journal, all articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (https://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
Journals System - logo
Scroll to top