EN PL
KRÓTKIE DONIESIENIE
Płodność, planowanie ciąży i farmakoterapia w okresie ciąży, połogu i karmienia piersią u chorych na reumatoidalne zapalenie stawów oraz inne zapalne choroby stawów
 
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Data nadesłania: 19-12-2013
 
 
Data akceptacji: 10-02-2014
 
 
Data publikacji online: 23-03-2014
 
 
Data publikacji: 28-02-2014
 
 
Reumatologia 2014;52(1):7-21
 
SŁOWA KLUCZOWE
DZIEDZINY
STRESZCZENIE
Szczyt zachorowań w przypadku większości zapalnych chorób stawów (ZChS) przypada na 2.–4. dekadę życia, a więc dotyczy osób w wieku reprodukcyjnym. Wyniki badań populacyjnych wskazują, że choroby te mogą wywierać wpływ zarówno na płodność pacjentów, planowanie rodziny, przebieg ciąży, jak i dalszy rozwój dziecka. Wykazano także, że kobiety chore na ZChS w porównaniu ze zdrowymi kobietami rzadziej i później decydują się na pierwsze i następne dziecko, a odstęp między kolejnymi ciążami jest dłuższy. Celem farmakoterapii u kobiety z ZChS, która planuje ciążę, jest skuteczne zahamowanie aktywności zapalnej oraz utrzymanie remisji lub małej aktywności choroby w czasie ciąży i po jej zakończeniu. Odpowiednie do stosowania w okresie prekoncepcji i ciąży są następujące leki modyfikujące przebieg choroby: chlorochina, hydroksychlorochina, sulfasalazyna, azatiopryna, cyklosporyna A, glikokortykosteroidy oraz niesteroidowe leki przeciwzapalne. Spośród syntetycznych leków modyfikujących przebieg choroby nie należy stosować: metotreksatu, leflunomidu, cyklofosfamidu oraz mykofenolanu mofetylu, a z leków biologicznych: abataceptu, tocilizumabu i rytuksymabu.
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Copyright: © Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie. This is an Open Access journal, all articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (https://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
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