PRACA PRZEGLĄDOWA
Zespoły neuropsychiatryczne u chorych na toczeń rumieniowaty układowy
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Data publikacji online: 21-12-2012
Reumatologia 2012;50(6):493-500
SŁOWA KLUCZOWE
STRESZCZENIE
Toczeń rumieniowaty układowy (TRU) jest chorobą zapalną o podłożu autoimmunizacyjnym, która prowadzi do uszkodzenia wielu tkanek i narządów, w tym ośrodkowego i obwodowego układu nerwowego. Ze względu na różnorodność objawów neurologicznych i psychiatrycznych związanych z toczniem Amerykańskie Towarzystwo Reumatologiczne w 1999 r. wyodrębniło 19 zespołów neuropsychiatrycznych, które mogą wystąpić w przebiegu TRU, i ustaliło dla nich szczegółowe kryteria rozpoznania (tab. I). Do zajęcia układu nerwowego dochodzi stosunkowo często, a zespoły neuropsychiatryczne korelują z cięższym przebiegiem choroby i przyczyniają się do niekorzystnego rokowania.
W pracy zaprezentowano objawy kliniczne TRU, z zajęciem ośrodkowego układu nerwowego, z uwzględnieniem zespołów neurologicznych zaproponowanych przez Amerykańskie Towarzystwo Reumatologiczne, oraz przedstawiono najnowsze rekomendacje dotyczące postępowania diagnostycznego i terapeutycznego wg Europejskiej Ligi do Walki z Reumatyzmem (EULAR).
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