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PRACA PRZEGLĄDOWA
Interleukina 6 – znaczenie biologiczne i rola w patogenezie reumatoidalnego zapalenia stawów
 
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Data publikacji online: 01-04-2009
 
 
Reumatologia 2009;47(1):24-33
 
SŁOWA KLUCZOWE
STRESZCZENIE
Interleukina 6 (IL-6) jest cytokiną plejotropową, oddziałującą wielokierunkowo na komórki układu odporności wrodzonej i nabytej. Uznaje się ją za jeden z kluczowych czynników regulujących mechanizmy obronne organizmu. Główną rolą tej cytokiny jest inicjowanie i regulacja ostrej odpowiedzi zapalnej oraz ułatwianie rozwoju i ukierunkowanie odpowiedzi nabytej. Interleukina 6 wykazuje także wiele działań ogólnoustrojowych. Wzmożone wytwarzanie tej cytokiny promuje przejście reakcji zapalnej w fazę chroniczną i przyczynia się do rozwoju niektórych chorób. W artykule omówiono strukturę IL-6 i jej receptorów, drogi przekazywania sygnału aktywacyjnego, właściwości biologiczne tej cytokiny oraz rolę w rozwoju doświadczalnego zapalenia stawów u zwierząt i w patogenezie reumatoidalnego zapalenia stawów. Przedstawione dane wskazują, że w reumatoidalnym zapaleniu stawów blokowanie aktywności IL-6 może być użytecznym postępowaniem terapeutycznym i ma niezaprzeczalne uzasadnienie naukowe.
 
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