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PRACA PRZEGLĄDOWA
Szpik kostny – funkcje fizjologiczne i udział w patogenezie reumatoidalnego zapalenia stawów
 
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Data publikacji online: 21-09-2010
 
 
Reumatologia 2010;48(4):247-256
 
SŁOWA KLUCZOWE
STRESZCZENIE
Wyniki badań prowadzonych w ostatnich latach wskazują, że szpik kostny funkcjonuje nie tylko jako narząd krwiotwórczy, lecz również jako wtórny narząd limfatyczny, w którym może być zainicjowana odpowiedź immunologiczna. Dane eksperymentalne i obserwacje kliniczne wskazują, że szpik kostny uczestniczy w rozwoju reumatoidalnego zapalenia stawów, ponieważ jest miejscem akumulacji aktywowanych limfocytów i wytwarzania czynników prozapalnych. W artykule opisano w zarysie rolę szpiku kostnego w prawidłowej (fizjologicznej) odpowiedzi immunologicznej. Przedstawiono również wyniki badań eksperymentalnych i klinicznych, które potwierdzają udział szpiku kostnego w patogenezie reumatoidalnego zapalenia stawów.
 
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